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GRIN3B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642152

GRIN3B is a NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. It is mediated by glycine. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRIN3B, Polyclonal Antibody
Full Product Name
GRIN3B, CT (GRIN3B, Glutamate [NMDA] receptor subunit 3B, N-methyl-D-aspartate receptor subtype 3B)
Product Gene Name
anti-GRIN3B antibody
Product Synonym Names
Anti -GRIN3B, CT (GRIN3B, Glutamate [NMDA] receptor subunit 3B, N-methyl-D-aspartate receptor subtype 3B)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
112,992 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (1000437..1009723). Location: 19p13.3
OMIM
606651
3D Structure
ModBase 3D Structure for O60391
Immunogen
GRIN3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 903-933 amino acids from the C-terminal region of human GRIN3B.

Product Categories/Family for anti-GRIN3B antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-GRIN3B antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GRIN3B antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-GRIN3B antibody

GRIN3B Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GRIN3B antibody detected the GRIN3B protein (arrow).
Rabbit Anti-GRIN3B Polyclonal Antibody – Cat# MBS642152

Immunohistochemistry (IHC) of anti-GRIN3B antibody

GRIN3B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GRIN3B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GRIN3B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS642152

Other Notes

Small volumes of anti-GRIN3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRIN3B purchase

MBS642152 is an antibody targeting GRIN3B. Also known as GRIN3B, CT (GRIN3B, Glutamate [NMDA] receptor subunit 3B, N-methyl-D-aspartate receptor subtype 3B). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIN3B. It may not necessarily be applicable to this product.

NCBI GI #
62988346
NCBI GeneID
116444
NCBI Accession #
NP_619635.1
UniProt Primary Accession #
O60391
UniProt Secondary Accession #
Q5EAK7; Q7RTW9
UniProt Related Accession #
O60391
GenBank Nucleotide #
NM_138690.1
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 3B
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
NCBI Official Symbol
GRIN3B
NCBI Official Synonym Symbols
NR3B; GluN3B
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 3B
UniProt Synonym Protein Names
N-methyl-D-aspartate receptor subtype 3B
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GRIN3B
UniProt Synonym Gene Names
GluN3B; NMDAR3B; NR3B
UniProt Entry Name
NMD3B_HUMAN
NCBI Protein Information
glutamate receptor ionotropic, NMDA 3B; NMDAR3B; NMDA receptor subunit 3B; glutamate [NMDA] receptor subunit 3B; N-methyl-D-aspartate receptor subtype 3B; NMDA type glutamate receptor subunit NR3B

UniProt Comments for GRIN3B

NMDAR3B: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: postsynaptic membrane; cell soma; dendrite; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: neurotransmitter binding; extracellular-glutamate-gated ion channel activity; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; cation channel activity; neurotransmitter receptor activity

Biological Process: synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; regulation of calcium ion transport; protein insertion into membrane
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Research Articles on GRIN3B

1. our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRIN3B antibody

 Reference Product  PubMed Publications
 GRIN3A antibody  >6 publications with GRIN3B and GRIN3A
 GRIN2B antibody  >3 publications with GRIN3B and GRIN2B
 GRIA3 antibody  >2 publications with GRIN3B and GRIA3
 GRIN2A antibody  >2 publications with GRIN3B and GRIN2A
 GRIA2 antibody  >1 publications with GRIN3B and GRIA2
 GRIN1 antibody  >1 publications with GRIN3B and GRIN1

Pathways associated with anti-GRIN3B antibody

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 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GRIN3B antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with GRIN3B and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with GRIN3B and Brain Diseases
 Cardiovascular Diseases Antibodies  >1 publications with GRIN3B and Cardiovascular Diseases
 Pain Antibodies  >1 publications with GRIN3B and Pain
 Cognition Disorders Antibodies  >1 publications with GRIN3B and Cognition Disorders
 Necrosis Antibodies  >1 publications with GRIN3B and Necrosis
 Learning Disorders Antibodies  >1 publications with GRIN3B and Learning Disorders
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