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OTOA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642192

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
OTOA, Polyclonal Antibody
Full Product Name
OTOA, NT (OTOA, Otoancorin)
Product Gene Name
anti-OTOA antibody
Product Synonym Names
Anti -OTOA, NT (OTOA, Otoancorin)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
128,533 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (21689835..21772050). Location: 16p12.2; 16p12.2
OMIM
607038
3D Structure
ModBase 3D Structure for Q7RTW8
Immunogen
OTOA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-127 amino acids from the N-terminal region of human OTOA.

Product Categories/Family for anti-OTOA antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-OTOA antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-OTOA antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-OTOA antibody

OTOA Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the OTOA antibody detected the OTOA protein (arrow).
Rabbit Anti-OTOA Polyclonal Antibody – Cat# MBS642192

Immunohistochemistry (IHC) of anti-OTOA antibody

OTOA Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of OTOA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-OTOA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS642192

Other Notes

Small volumes of anti-OTOA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OTOA purchase

MBS642192 is an antibody targeting OTOA. Also known as OTOA, NT (OTOA, Otoancorin). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OTOA. It may not necessarily be applicable to this product.

NCBI GI #
77404409
NCBI GeneID
146183
NCBI Accession #
NP_653273.3
UniProt Primary Accession #
Q7RTW8
UniProt Secondary Accession #
Q8NA86; Q96M76; A1L3A8; A2VDI0; B3KWU3; E9PF51
UniProt Related Accession #
Q7RTW8
GenBank Nucleotide #
NM_144672.3
NCBI Official Full Name
otoancorin isoform 1
NCBI Official Synonym Full Names
otoancorin
NCBI Official Symbol
OTOA
NCBI Official Synonym Symbols
CT108; DFNB22
UniProt Protein Name
Otoancorin
Protein Family
Otoancorin
UniProt Gene Name
OTOA
UniProt Entry Name
OTOAN_HUMAN
NCBI Protein Information
otoancorin; cancer/testis antigen 108

NCBI Summary for OTOA

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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UniProt Comments for OTOA

OTOA: May act as an adhesion molecule. Defects in OTOA are the cause of deafness autosomal recessive type 22 (DFNB22). DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the stereocilin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Cancer Testis Antigen (CTA); Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 16p12.2|16p12.2

Cellular Component: proteinaceous extracellular matrix; apical plasma membrane

Biological Process: sensory perception of sound; cell-matrix adhesion; transmission of nerve impulse

Disease: Deafness, Autosomal Recessive 22
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Research Articles on OTOA

1. Large deletions in OTOA gene is associated with hearing loss.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OTOA antibody

 Reference Product  PubMed Publications
 TECTA antibody  >1 publications with OTOA and TECTA

Diseases associated with anti-OTOA antibody

 Disease Name  Pubmed Publications
 Deafness, Autosomal Recessive 22 Antibodies  >1 publications with OTOA and Deafness, Autosomal Recessive 22

Organs/Tissues associated with anti-OTOA antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with OTOA and Testis
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