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PTPN14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642204

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PTPN14, Polyclonal Antibody
Full Product Name
PTPN14, CT (PTPN14, PEZ, Tyrosine-protein phosphatase non-receptor type 14, Protein-tyrosine phosphatase pez)
Product Gene Name
anti-PTPN14 antibody
Product Synonym Names
Anti -PTPN14, CT (PTPN14, PEZ, Tyrosine-protein phosphatase non-receptor type 14, Protein-tyrosine phosphatase pez)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
135,261 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (214521640..214725024, complement). Location: 1q32.2
OMIM
603155
3D Structure
ModBase 3D Structure for Q15678
Immunogen
PTPN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human PTPN14.

Product Categories/Family for anti-PTPN14 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-PTPN14 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PTPN14 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-PTPN14 antibody

PTPN14 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the PTPN14 antibody detected the PTPN14 protein (arrow).
Rabbit Anti-PTPN14 Polyclonal Antibody – Cat# MBS642204

Other Notes

Small volumes of anti-PTPN14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPN14 purchase

MBS642204 is an antibody targeting PTPN14. Also known as PTPN14, CT (PTPN14, PEZ, Tyrosine-protein phosphatase non-receptor type 14, Protein-tyrosine phosphatase pez). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN14. It may not necessarily be applicable to this product.

NCBI GI #
33878926
NCBI GeneID
5784
NCBI Accession #
AAH17300.1
UniProt Primary Accession #
Q15678
UniProt Secondary Accession #
Q5VSI0
UniProt Related Accession #
Q15678
NCBI Official Full Name
PTPN14 protein, partial
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 14
NCBI Official Symbol
PTPN14
NCBI Official Synonym Symbols
PEZ; PTP36
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 14
UniProt Synonym Protein Names
Protein-tyrosine phosphatase pez
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN14
UniProt Synonym Gene Names
PEZ; PTPD2
UniProt Entry Name
PTN14_HUMAN
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 14; protein-tyrosine phosphatase pez; cytoskeletal-associated protein tyrosine phosphatase

UniProt Comments for PTPN14

PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nucleus

Molecular Function: protein binding; transcription cofactor activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding

Biological Process: negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lymphangiogenesis; protein amino acid dephosphorylation; regulation of protein export from nucleus

Disease: Choanal Atresia And Lymphedema
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Research Articles on PTPN14

1. Data show that p130 Crk-associated substrate is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas phosphorylation at tyrosine residue 128 in colorectal cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPN14 antibody

 Reference Product  PubMed Publications
 PTPN13 antibody  >2 publications with PTPN14 and PTPN13
 CTNNB1 antibody  >1 publications with PTPN14 and CTNNB1

Diseases associated with anti-PTPN14 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with PTPN14 and Neoplasms
 Lung Neoplasms Antibodies  >4 publications with PTPN14 and Lung Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with PTPN14 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >1 publications with PTPN14 and Neoplasms, Experimental
 Hyperplasia Antibodies  >1 publications with PTPN14 and Hyperplasia
 Disease Models, Animal Antibodies  >1 publications with PTPN14 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >1 publications with PTPN14 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >1 publications with PTPN14 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with PTPN14 and Liver Diseases
 CHOANAL ATRESIA AND LYMPHEDEMA Antibodies  >1 publications with PTPN14 and CHOANAL ATRESIA AND LYMPHEDEMA

Organs/Tissues associated with anti-PTPN14 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with PTPN14 and Lung
 Vascular Antibodies  >3 publications with PTPN14 and Vascular
 Blood Antibodies  >2 publications with PTPN14 and Blood
 Prostate Antibodies  >1 publications with PTPN14 and Prostate
 Muscle Antibodies  >1 publications with PTPN14 and Muscle
 Placenta Antibodies  >1 publications with PTPN14 and Placenta
 Heart Antibodies  >1 publications with PTPN14 and Heart
 Brain Antibodies  >1 publications with PTPN14 and Brain
 Liver Antibodies  >1 publications with PTPN14 and Liver
 Kidney Antibodies  >1 publications with PTPN14 and Kidney
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