Rabbit Anti-THOC6 Polyclonal Antibody – Cat# MBS642206

THOC6 Antibody (Center) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the THOC6 antibody detected the THOC6 protein (arrow).

THOC6 Antibody – Rabbit Polyclonal

Name: THOC6 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS642206
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642206

Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

THOC6, Polyclonal Antibody

Full Product Name

THOC6, ID (THOC6, WDR58, THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, WD repeat-containing protein 58)

Product Gene Name

anti-THOC6 antibody

Product Synonym Names

Anti -THOC6, ID (THOC6, WDR58, THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, WD repeat-containing protein 58)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human, mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

37,535 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (3074032..3077756). Location: 16p13.3

3D Structure

ModBase 3D Structure for Q86W42

Immunogen

THOC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the Central region of human THOC6.

Product Categories/Family for anti-THOC6 antibody

Antibodies; Abs to WD Repeat Proteins

Applications Tested/Suitable for anti-THOC6 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-THOC6 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-THOC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THOC6 purchase

MBS642206 is an antibody targeting THOC6. Also known as THOC6, ID (THOC6, WDR58, THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, WD repeat-containing protein 58). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for THOC6. It may not necessarily be applicable to this product.

NCBI GI #

215272341

NCBI GeneID

79228

NCBI Accession #

NP_001135822.1

UniProt Primary Accession #

Q86W42

UniProt Secondary Accession #

Q8NBR1; Q9BTV9; B2RA85

UniProt Related Accession #

Q86W42

GenBank Nucleotide #

NM_001142350.1

NCBI Official Full Name

THO complex subunit 6 homolog isoform 2

NCBI Official Synonym Full Names

THO complex 6 homolog (Drosophila)

NCBI Official Symbol

THOC6

NCBI Official Synonym Symbols

BBIS; WDR58; fSAP35

UniProt Protein Name

THO complex subunit 6 homolog

UniProt Synonym Protein Names

Functional spliceosome-associated protein 35; fSAP35; WD repeat-containing protein 58

Protein Family

THO complex

UniProt Gene Name

THOC6

UniProt Synonym Gene Names

WDR58; fSAP35

UniProt Entry Name

THOC6_HUMAN

NCBI Protein Information

THO complex subunit 6 homolog; WD repeat domain 58; WD repeat-containing protein 58; functional spliceosome-associated protein 35

UniProt Comments for THOC6

THOC6: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the WD repeat THOC6 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; nuclear speck; nucleus

Molecular Function: RNA binding

Biological Process: mRNA export from nucleus; central nervous system development; apoptosis; RNA splicing; intronless viral mRNA export from host nucleus; mRNA processing; negative regulation of apoptosis

Disease: Beaulieu-boycott-innes Syndrome

Research Articles on THOC6

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-THOC6 antibody

Reference Product	PubMed Publications
THOC4 antibody	>1 publications with THOC6 and THOC4
THOC5 antibody	>1 publications with THOC6 and THOC5
THOC7 antibody	>1 publications with THOC6 and THOC7
THOC1 antibody	>1 publications with THOC6 and THOC1
THOC2 antibody	>1 publications with THOC6 and THOC2

Pathways associated with anti-THOC6 antibody

Products by Pathway	Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
THC Complex Pathway antibodies	THC Complex Pathway Diagram
TREX Complex Pathway antibodies	TREX Complex Pathway Diagram