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NFATC2IP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642266

Plays a role in the inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production. More details

$970 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NFATC2IP, Polyclonal Antibody
Full Product Name
NFATC2IP (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein, FLJ14639, MGC126790, MGC138387)
Product Gene Name
Product Synonym Names
Anti -NFATC2IP (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein, FLJ14639, MGC126790, MGC138387)
Immunogen Sequence
MSEPLQSVVD HMATHLGVSP SRILLLFGET ELSPTATPRT LKLGVADIID CVVLTSSPEA TETSQQLQLR VQGKEKHQTL EVSLSRDSPL KTLMSHYEEA MGLSGRKLSF FFDGTKLSGR ELPADLGMES GDLIEVWG
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human NFATC2IP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,817 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (28962318..28977786). Location: 16p11.2
OMIM
614525
3D Structure
ModBase 3D Structure for Q8NCF5
Immunogen
Full length human NFATC2IP, aa1-138 (AAH21551.1).
Applications Tested/Suitable for anti-NFATC2IP antibody
Western Blot (WB)
Application Notes for anti-NFATC2IP antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-NFATC2IP antibody

Western Blot analysis of NFATC2IP expression in transfected 293T cell line by NFATC2IP polyclonal antibody. Lane 1: NFATC2IP transfected lysate (15.1kD). Lane 2: Non-transfected lysate.
Rabbit Anti-NFATC2IP Polyclonal Antibody – Cat# MBS642266

Other Notes

Small volumes of anti-NFATC2IP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NFATC2IP purchase

MBS642266 is an antibody targeting NFATC2IP. Also known as NFATC2IP (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein, FLJ14639, MGC126790, MGC138387). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NFATC2IP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NFATC2IP protein, partial
NCBI Official Synonym Full Names
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NCBI Official Symbol
NFATC2IP
NCBI Official Synonym Symbols
ESC2; NIP45; RAD60
UniProt Protein Name
NFATC2-interacting protein
UniProt Synonym Protein Names
45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
UniProt Gene Name
NFATC2IP
UniProt Synonym Gene Names
NIP45; 45 kDa NFAT-interacting protein
UniProt Entry Name
NF2IP_HUMAN
NCBI Protein Information
NFATC2-interacting protein; 45 kDa NFAT-interacting protein; 45 kDa NF-AT-interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein

UniProt Comments for NFATC2IP

NFATC2IP: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; nucleus

Biological Process: cytokine production; positive regulation of transcription from RNA polymerase II promoter
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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