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AEBP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642340

The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which… More details

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Product Overview

Online Datasheet in PDF
Product Name
AEBP1, Polyclonal Antibody
Full Product Name
AEBP1, ID (AEBP1, ACLP, Adipocyte enhancer-binding protein 1, Aortic carboxypeptidase-like protein)
Product Gene Name
anti-AEBP1 antibody
Product Synonym Names
Anti -AEBP1, ID (AEBP1, ACLP, Adipocyte enhancer-binding protein 1, Aortic carboxypeptidase-like protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
130,929 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (44143960..44154164). Location: 7p13
OMIM
602981
3D Structure
ModBase 3D Structure for Q8IUX7
Immunogen
AEBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-372 amino acids from the Central region of human AEBP1.

Product Categories/Family for anti-AEBP1 antibody

Antibodies; Abs to Obesity Proteins
Applications Tested/Suitable for anti-AEBP1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-AEBP1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-AEBP1 antibody

AEBP1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).
Rabbit Anti-AEBP1 Polyclonal Antibody – Cat# MBS642340

Western Blot (WB) of anti-AEBP1 antibody

AEBP1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AEBP1 antibody detected the AEBP1 protein (arrow).
Rabbit Anti-AEBP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS642340

Other Notes

Small volumes of anti-AEBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AEBP1 purchase

MBS642340 is an antibody targeting AEBP1. Also known as AEBP1, ID (AEBP1, ACLP, Adipocyte enhancer-binding protein 1, Aortic carboxypeptidase-like protein). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AEBP1. It may not necessarily be applicable to this product.

NCBI GI #
53692189
NCBI GeneID
165
NCBI Accession #
NP_001120.3
UniProt Primary Accession #
Q8IUX7
UniProt Secondary Accession #
Q14113; Q59ER7; Q6ZSC7; Q7KZ79
UniProt Related Accession #
Q8IUX7
GenBank Nucleotide #
NM_001129.4
NCBI Official Full Name
adipocyte enhancer-binding protein 1
NCBI Official Synonym Full Names
AE binding protein 1
NCBI Official Symbol
AEBP1
NCBI Official Synonym Symbols
ACLP
UniProt Protein Name
Adipocyte enhancer-binding protein 1
UniProt Synonym Protein Names
Aortic carboxypeptidase-like protein
Protein Family
Adipocyte enhancer-binding protein
UniProt Gene Name
AEBP1
UniProt Synonym Gene Names
ACLP; AE-binding protein 1
UniProt Entry Name
AEBP1_HUMAN
NCBI Protein Information
adipocyte enhancer-binding protein 1; aortic carboxypeptidase-like protein

NCBI Summary for AEBP1

This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
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UniProt Comments for AEBP1

AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Transcription factor

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus

Molecular Function: calmodulin binding; zinc ion binding; carboxypeptidase activity; transcription factor activity; transcription corepressor activity; metallocarboxypeptidase activity

Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development
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Research Articles on AEBP1

1. There is no statistically significant differences in the frequency of variants in AEBP1 among the gastroschisis case group compared to a Caucasian control group.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AEBP1 antibody

 Reference Product  PubMed Publications
 PTEN antibody  >4 publications with AEBP1 and PTEN
 TAGLN antibody  >1 publications with AEBP1 and TAGLN

Diseases associated with anti-AEBP1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with AEBP1 and Inflammation
 Atherosclerosis Antibodies  >4 publications with AEBP1 and Atherosclerosis
 Necrosis Antibodies  >3 publications with AEBP1 and Necrosis
 Neoplasms Antibodies  >2 publications with AEBP1 and Neoplasms
 HIV Infections Antibodies  >1 publications with AEBP1 and HIV Infections
 Genital Diseases, Male Antibodies  >1 publications with AEBP1 and Genital Diseases, Male
 Prostatic Neoplasms Antibodies  >1 publications with AEBP1 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >1 publications with AEBP1 and Prostatic Diseases

Organs/Tissues associated with anti-AEBP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >10 publications with AEBP1 and Vascular
 Muscle Antibodies  >10 publications with AEBP1 and Muscle
 Connective Tissue Antibodies  >8 publications with AEBP1 and Connective Tissue
 Adipose Tissue Antibodies  >8 publications with AEBP1 and Adipose Tissue
 Bone Antibodies  >8 publications with AEBP1 and Bone
 Embryonic Tissue Antibodies  >6 publications with AEBP1 and Embryonic Tissue
 Blood Antibodies  >4 publications with AEBP1 and Blood
 Lung Antibodies  >3 publications with AEBP1 and Lung
 Heart Antibodies  >3 publications with AEBP1 and Heart
 Brain Antibodies  >3 publications with AEBP1 and Brain
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