BHLHE41 Antibody – Goat Polyclonal

DEC-2 is a 54-56kD Class B member of the bHLH superfamily of proteins. It utilizes both DNA binding and protein-protein interaction to mediate E-box transcriptional repression. Physiologically, DEC-2 is proposed to be a regulator of the sleep cycle, particularly during periods of sleep deprivation. It also interacts with HIF-1 alpha neutralizing its activation of the VEGF gene during hypoxia. Human DEC-2 is 482aa in length. It contains a DNA binding motif aa45-57, an HLH region aa58-100, an Orange domain that may impart specificity to protein-protein interactions aa131-166 and a Gly/Ala-rich region aa297-431. DEC-2 forms homodimers, and heterodimers with MyoD and E-proteins. There is one potential alternate start site at Met280. Over aa101-287, there is less than 60% aa identity between human and mouse DEC-2.

Small volumes of anti-BHLHE41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS642347 is an antibody targeting BHLHE41. Also known as SHARP1 (Class E Basic Helix-loop-helix Protein 41, bHLHe41, Class B Basic Helix-loop-helix Protein 3, bHLHb3, Differentially Expressed in Chondrocytes Protein 2, hDEC2, Enhancer-of-split and Hairy-related Protein 1, SHARP-1, BHLHE41, BHLHB3, DEC2). Reactive in Human. Host: Goat.