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LPIN1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642396

LPIN1 represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LPIN1, Monoclonal Antibody
Full Product Name
LPIN1 (KIAA0188, Phosphatidate Phosphatase LPIN1, Lipin-1)
Product Gene Name
anti-Lpin1 antibody
Product Synonym Names
Anti -LPIN1 (KIAA0188, Phosphatidate Phosphatase LPIN1, Lipin-1)
Immunogen Sequence
EPFYAAFGNR PADVYSYKQV GVSLNRIFTV NPKGELVQEH AKTNISSYVR LCEVVDHVFP LLKRSHSSDF PCSDTFSNFT FWREPLPPFE NQDIHSASA*
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
3D9
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human LPIN1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
102,002 Da
Chromosome Location
Chromosome: 12; NC_000078.6 (16535669..16589770, complement). Location: 12 A1.1; 12 7.9 cM
3D Structure
ModBase 3D Structure for Q91ZP3
Immunogen
Partial recombinant corresponding to aa792-891 from LPIN1 (NP_663731) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-Lpin1 antibody

Antibodies; Abs to Protein Phosphatases
Applications Tested/Suitable for anti-Lpin1 antibody
ELISA (EL/EIA)
Application Notes for anti-Lpin1 antibody
Suitable for use in ELISA.

Western Blot (WB) of anti-Lpin1 antibody

Western Blot analysis of LPIN1 expression in transfected 293T cell line by LPIN1 monoclonal antibody.|Lane 1: LPIN1 transfected lysate (Predicted MW: 98.7kD).|Lane 2: Non-transfected lysate.
Mouse Anti-LPIN1 Monoclonal Antibody – Cat# MBS642396

Other Notes

Small volumes of anti-Lpin1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lpin1 purchase

MBS642396 is an antibody targeting Lpin1. Also known as LPIN1 (KIAA0188, Phosphatidate Phosphatase LPIN1, Lipin-1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Lpin1. It may not necessarily be applicable to this product.

NCBI GI #
7264655
NCBI GeneID
14245
NCBI Accession #
AAF44296.1
UniProt Primary Accession #
Q91ZP3
UniProt Secondary Accession #
Q9CQI2; Q9JLG6
UniProt Related Accession #
Q91ZP3
NCBI Official Full Name
Lpin1
NCBI Official Synonym Full Names
lipin 1
NCBI Official Symbol
Lpin1
NCBI Official Synonym Symbols
fld; Lipin1; Kiaa0188; mKIAA0188; 4631420P06
UniProt Protein Name
Phosphatidate phosphatase LPIN1
UniProt Synonym Protein Names
Fatty liver dystrophy protein; Lipin-1
Protein Family
Phosphatidate phosphatase
UniProt Gene Name
Lpin1
UniProt Synonym Gene Names
Fld
UniProt Entry Name
LPIN1_MOUSE
NCBI Protein Information
phosphatidate phosphatase LPIN1; lipin-1; fatty liver dystrophy protein

UniProt Comments for Lpin1

LPIN1: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family.

Protein type: EC 3.1.3.4; Phosphatase, lipid

Cellular Component: mitochondrial outer membrane; transcription factor complex; nuclear membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; nucleus

Molecular Function: protein binding; peroxisome proliferator activated receptor binding; hydrolase activity; phosphatidate phosphatase activity; histone deacetylase binding; transcription coactivator activity

Biological Process: fat cell differentiation; mitochondrial fission; transcription, DNA-dependent; regulation of fat cell differentiation; triacylglycerol biosynthetic process; fatty acid catabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; dephosphorylation; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; actin cytoskeleton reorganization; ruffle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; triacylglycerol mobilization
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Research Articles on Lpin1

1. lipin1 functions as a key regulator of PPARgamma activity through its ability to release co-repressors and recruit co-activators via a mechanism other than PPARalpha activation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Lpin1 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram

Diseases associated with anti-Lpin1 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >33 publications with Lpin1 and Fatty Liver
 Insulin Resistance Antibodies  >32 publications with Lpin1 and Insulin Resistance
 Liver Diseases Antibodies  >19 publications with Lpin1 and Liver Diseases
 Inflammation Antibodies  >11 publications with Lpin1 and Inflammation
 Necrosis Antibodies  >6 publications with Lpin1 and Necrosis
 Nervous System Diseases Antibodies  >5 publications with Lpin1 and Nervous System Diseases
 Weight Loss Antibodies  >5 publications with Lpin1 and Weight Loss
 Muscular Diseases Antibodies  >4 publications with Lpin1 and Muscular Diseases
 Glucose Intolerance Antibodies  >3 publications with Lpin1 and Glucose Intolerance
 Anemia Antibodies  >3 publications with Lpin1 and Anemia

Organs/Tissues associated with anti-Lpin1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >60 publications with Lpin1 and Liver
 Connective Tissue Antibodies  >30 publications with Lpin1 and Connective Tissue
 Muscle Antibodies  >28 publications with Lpin1 and Muscle
 Blood Antibodies  >24 publications with Lpin1 and Blood
 Heart Antibodies  >9 publications with Lpin1 and Heart
 Brain Antibodies  >9 publications with Lpin1 and Brain
 Kidney Antibodies  >5 publications with Lpin1 and Kidney
 Embryonic Tissue Antibodies  >4 publications with Lpin1 and Embryonic Tissue
 Ovary Antibodies  >4 publications with Lpin1 and Ovary
 Mammary Gland Antibodies  >4 publications with Lpin1 and Mammary Gland
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