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SEMA6A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642567

SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SEMA6A, Polyclonal Antibody
Full Product Name
SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1)
Product Gene Name
Product Synonym Names
Anti -SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
114,395 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (115779251..115910551, complement). Location: 5q23.1
OMIM
605885
3D Structure
ModBase 3D Structure for Q9H2E6
Immunogen
SEMA6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human SEMA6A.
Applications Tested/Suitable for anti-SEMA6A antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SEMA6A antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-SEMA6A antibody

SEMA6A Antibody (N-term) western blot analysis in A2058 cell line lysates (15ug/lane).This demonstrates the SEMA6A antibody detected the SEMA6A protein (arrow).
Rabbit Anti-SEMA6A Polyclonal Antibody – Cat# MBS642567

Other Notes

Small volumes of anti-SEMA6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEMA6A purchase

MBS642567 is an antibody targeting SEMA6A. Also known as SEMA6A, NT (SEMA6A, KIAA1368, SEMAQ, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA6A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
semaphorin-6A
NCBI Official Synonym Full Names
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NCBI Official Symbol
SEMA6A
NCBI Official Synonym Symbols
VIA; SEMA; HT018; SEMAQ; SEMA6A1
UniProt Protein Name
Semaphorin-6A
UniProt Synonym Protein Names
Semaphorin VIA; Sema VIA; Semaphorin-6A-1
Protein Family
UniProt Gene Name
SEMA6A
UniProt Synonym Gene Names
KIAA1368; SEMAQ; Sema VIA; SEMA6A-1
UniProt Entry Name
SEM6A_HUMAN
NCBI Protein Information
semaphorin-6A; SEMA6A-1; sema VIa; semaphorin VIA; semaphorin 6A-1; semaphorin-6A-1

NCBI Summary for SEMA6A

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

UniProt Comments for SEMA6A

SEMA6A: a single-pass type I membrane protein of the semaphorin family that can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. Interacts with EVL. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: axon; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity

Biological Process: axon guidance; nervous system development; organ morphogenesis; cell surface receptor linked signal transduction; apoptosis; cytoskeleton organization and biogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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