MYBBP1A Antibody – Rabbit Polyclonal

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

MYBBP1A: may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PGC-1 (PPAR gamma coactivator-1): this interaction is abrogated when PGC-1 is phosphorylated by ERK1. Binds to and stimulates transcription by AhR. Binds to KPNA2. Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on exportin 1. Predominantly nucleolar. Two alternatively spliced isoforms have been described.

Protein type: DNA replication; DNA-binding; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: membrane; NLS-dependent protein nuclear import complex; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; DNA-directed DNA polymerase activity; transcription corepressor activity; transcription factor binding

Biological Process: osteoblast differentiation; cellular response to glucose starvation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleocytoplasmic transport; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent