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GOLGA2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642641

MBS642641 is an antibody targeting GOLGA2. Also known as GOLGA2 (Golgin Subfamily A Member 2, 130 kDa cis-Golgi Matrix Protein, GM130 Autoantigen, Golgin-95, GM130, MGC20672). Reactive in Human. Host: Mouse. Golgi auto-antigen; probably involved in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GOLGA2, Monoclonal Antibody
Full Product Name
GOLGA2 (Golgin Subfamily A Member 2, 130 kDa cis-Golgi Matrix Protein, GM130 Autoantigen, Golgin-95, GM130, MGC20672)
Product Gene Name
anti-GOLGA2 antibody
Product Synonym Names
Anti -GOLGA2 (Golgin Subfamily A Member 2, 130 kDa cis-Golgi Matrix Protein, GM130 Autoantigen, Golgin-95, GM130, MGC20672)
Immunogen Sequence
EQAEARRQIL ETMQNDRTTI SRALSQNREL KEQLAELQSG FVKLTNENME ITSALQSEQH VKRELGKKLG ELQEKLSELK ETVELKSQEA QSLQQQRDQY LGHLQQYVAA YQQLTSEKEV
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2C6
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human GOLGA2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
113,086 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (131018108..131038286, complement). Location: 9q34.11
OMIM
602580
3D Structure
ModBase 3D Structure for Q08379
Immunogen
Partial recombinant corresponding to aa1-120 from human GOLGA2 (AAH06381.1) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-GOLGA2 antibody

Antibodies; Abs to Golgi Proteins
Applications Tested/Suitable for anti-GOLGA2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-GOLGA2 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-GOLGA2 antibody

Western Blot detection against Immunogen (38.94kD).
Mouse Anti-GOLGA2 Monoclonal Antibody – Cat# MBS642641

Western Blot (WB) of anti-GOLGA2 antibody

GOLGA2 monoclonal antibody. Western Blot analysis of GOLGA2 expression in human spleen.
Mouse Anti-GOLGA2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS642641

Testing Data of anti-GOLGA2 antibody

Detection limit for recombinant GST tagged GOLGA2 is 0.03ng/ml as a capture antibody.
Mouse Anti-GOLGA2 Monoclonal Antibody, Testing Data – Cat# MBS642641

Other Notes

Small volumes of anti-GOLGA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GOLGA2. It may not necessarily be applicable to this product.

NCBI GI #
194097392
NCBI GeneID
2801
NCBI Accession #
NP_004477.3
UniProt Primary Accession #
Q08379
UniProt Secondary Accession #
Q6GRM9; Q9BRB0; Q9NYF9
UniProt Related Accession #
Q08379
GenBank Nucleotide #
NM_004486.4
NCBI Official Full Name
Golgin subfamily A member 2
NCBI Official Synonym Full Names
golgin A2
NCBI Official Symbol
GOLGA2
NCBI Official Synonym Symbols
GM130
UniProt Protein Name
Golgin subfamily A member 2
UniProt Synonym Protein Names
130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; Golgin-95
Protein Family
Golgin subfamily
UniProt Gene Name
GOLGA2
UniProt Synonym Gene Names
GM130
UniProt Entry Name
GOGA2_HUMAN
NCBI Protein Information
Golgin subfamily A member 2; golgin-95; SY11 protein; GM130 autoantigen; Golgi matrix protein GM130; 130 kDa cis-Golgi matrix protein; golgi autoantigen, golgin subfamily a, 2

NCBI Summary for GOLGA2

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]
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UniProt Comments for GOLGA2

GM130: Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1. Belongs to the GOLGA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: Golgi membrane; Golgi apparatus; cis-Golgi network; nucleus; ER to Golgi transport vesicle

Molecular Function: protein binding; syntaxin binding; protein kinase binding

Biological Process: mitotic cell cycle; negative regulation of protein binding
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Research Articles on GOLGA2

1. Induction of autophagy by shGOLGA2 may induce cell death rather than cell survival. Downregulation of GOLGA2/GM130 may be a potential therapeutic option for lung cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GOLGA2 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Golgi Cisternae Pericentriolar Stack Reorganization Pathway antibodies  Golgi Cisternae Pericentriolar Stack Reorganization Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 PLK1 Signaling Events Pathway antibodies  PLK1 Signaling Events Pathway Diagram

Diseases associated with anti-GOLGA2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >1 publications with GOLGA2 and Carcinoma
 Immune System Diseases Antibodies  >1 publications with GOLGA2 and Immune System Diseases
 Lung Neoplasms Antibodies  >1 publications with GOLGA2 and Lung Neoplasms
 Neoplasms Antibodies  >1 publications with GOLGA2 and Neoplasms
 Adenocarcinoma Antibodies  >1 publications with GOLGA2 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with GOLGA2 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >1 publications with GOLGA2 and Necrosis

Organs/Tissues associated with anti-GOLGA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >3 publications with GOLGA2 and Nerve
 Eye Antibodies  >2 publications with GOLGA2 and Eye
 Blood Antibodies  >1 publications with GOLGA2 and Blood
 Heart Antibodies  >1 publications with GOLGA2 and Heart
 Muscle Antibodies  >1 publications with GOLGA2 and Muscle
 Lung Antibodies  >1 publications with GOLGA2 and Lung
 Liver Antibodies  >1 publications with GOLGA2 and Liver
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