Rabbit Anti-NPAS3 Polyclonal Antibody – Cat# MBS642758

Human Testis (formalin-fixed, paraffin-embedded) stained with NPAS3 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.

NPAS3 Antibody – Rabbit Polyclonal

Name: NPAS3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS642758
Price: 785 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642758

May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness. More details

$785 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NPAS3, Polyclonal Antibody

Full Product Name

NPAS3, NT (Neuronal PAS Domain-containing Protein 3, Neuronal PAS3, Basic-helix-loop-helix-PAS Protein MOP6, Class E Basic Helix-loop-helix Protein 12, bHLHe12, Member of PAS Protein 6, PAS Domain-containing Protein 6, BHLHE12, MOP6, PASD6)

Product Gene Name

anti-NPAS3 antibody

Product Synonym Names

Anti -NPAS3, NT (Neuronal PAS Domain-containing Protein 3, Neuronal PAS3, Basic-helix-loop-helix-PAS Protein MOP6, Class E Basic Helix-loop-helix Protein 12, bHLHe12, Member of PAS Protein 6, PAS Domain-containing Protein 6, BHLHE12, MOP6, PASD6)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human NPAS3. Species sequence homology: Mouse and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

100,805 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (33404115..34273382). Location: 14q13.1

OMIM

609430

3D Structure

ModBase 3D Structure for Q8IXF0

Immunogen

Synthetic peptide corresponding to 28aa from human NPAS3 at N-terminal (KLH).

Product Categories/Family for anti-NPAS3 antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-NPAS3 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-NPAS3 antibody

Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.5-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Other Notes

Small volumes of anti-NPAS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPAS3 purchase

MBS642758 is an antibody targeting NPAS3. Also known as NPAS3, NT (Neuronal PAS Domain-containing Protein 3, Neuronal PAS3, Basic-helix-loop-helix-PAS Protein MOP6, Class E Basic Helix-loop-helix Protein 12, bHLHe12, Member of PAS Protein 6, PAS Domain-containing Protein 6, BHLHE12, MOP6, PASD6). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPAS3. It may not necessarily be applicable to this product.

NCBI GI #

260064034

NCBI GeneID

64067

NCBI Accession #

NP_001158221.1

UniProt Primary Accession #

Q8IXF0

UniProt Secondary Accession #

Q86US6; Q86US7; Q8IXF2; Q9BY81; Q9H323; Q9Y4L8

UniProt Related Accession #

Q8IXF0

GenBank Nucleotide #

NM_001164749.1

NCBI Official Full Name

neuronal PAS domain-containing protein 3 isoform 1

NCBI Official Synonym Full Names

neuronal PAS domain protein 3

NCBI Official Symbol

NPAS3

NCBI Official Synonym Symbols

MOP6; PASD6; bHLHe12

UniProt Protein Name

Neuronal PAS domain-containing protein 3

UniProt Synonym Protein Names

Basic-helix-loop-helix-PAS protein MOP6; Class E basic helix-loop-helix protein 12; bHLHe12; Member of PAS protein 6; PAS domain-containing protein 6

Protein Family

Neuronal PAS domain-containing protein

UniProt Gene Name

NPAS3

UniProt Synonym Gene Names

BHLHE12; MOP6; PASD6; Neuronal PAS3; bHLHe12

UniProt Entry Name

NPAS3_HUMAN

NCBI Protein Information

neuronal PAS domain-containing protein 3; neuronal PAS3; member of PAS protein 6; PAS domain-containing protein 6; basic-helix-loop-helix-PAS protein MOP6; class E basic helix-loop-helix protein 12

NCBI Summary for NPAS3

This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

UniProt Comments for NPAS3

NPAS3: May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness. A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13). 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q13.1

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein dimerization activity; signal transducer activity; DNA binding

Biological Process: startle response; transcription, DNA-dependent; maternal behavior; positive regulation of transcription, DNA-dependent; locomotory behavior; signal transduction

Research Articles on NPAS3

1. During human postnatal cortical development, there was decreased NPAS3 mRNA yet increased NPAS3 protein expression, suggesting the involvement of posttranscriptional regulation, which results show is modified by miR-17.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPAS3 antibody

Reference Product	PubMed Publications
GRIK4 antibody	>2 publications with NPAS3 and GRIK4
FGF10 antibody	>1 publications with NPAS3 and FGF10
FGF9 antibody	>1 publications with NPAS3 and FGF9
XKR4 antibody	>1 publications with NPAS3 and XKR4

Diseases associated with anti-NPAS3 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>4 publications with NPAS3 and Congenital Abnormalities
Brain Diseases Antibodies	>3 publications with NPAS3 and Brain Diseases
Nervous System Malformations Antibodies	>2 publications with NPAS3 and Nervous System Malformations
Neoplasms Antibodies	>2 publications with NPAS3 and Neoplasms
Fetal Diseases Antibodies	>1 publications with NPAS3 and Fetal Diseases
Learning Disorders Antibodies	>1 publications with NPAS3 and Learning Disorders
Inflammation Antibodies	>1 publications with NPAS3 and Inflammation
Memory Disorders Antibodies	>1 publications with NPAS3 and Memory Disorders
Cognition Disorders Antibodies	>1 publications with NPAS3 and Cognition Disorders

Organs/Tissues associated with anti-NPAS3 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>1 publications with NPAS3 and Embryonic Tissue