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FGD6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642775

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGD6, Polyclonal Antibody
Full Product Name
FGD6, CT (FGD6, KIAA1362, ZFYVE24, FYVE, RhoGEF and PH domain-containing protein 6, Zinc finger FYVE domain-containing protein 24)
Product Gene Name
Product Synonym Names
Anti -FGD6, CT (FGD6, KIAA1362, ZFYVE24, FYVE, RhoGEF and PH domain-containing protein 6, Zinc finger FYVE domain-containing protein 24)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
160,816 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (95470525..95611240, complement). Location: 12q22
OMIM
613520
3D Structure
ModBase 3D Structure for Q6ZV73
Immunogen
FGD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1331-1359 amino acids from the C-terminal region of human FGD6.
Applications Tested/Suitable for anti-FGD6 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FGD6 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-FGD6 antibody

FGD6 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FGD6 antibody detected the FGD6 protein (arrow).
Rabbit Anti-FGD6 Polyclonal Antibody – Cat# MBS642775

Immunohistochemistry (IHC) of anti-FGD6 antibody

FGD6 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FGD6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-FGD6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS642775

Other Notes

Small volumes of anti-FGD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGD6 purchase

MBS642775 is an antibody targeting FGD6. Also known as FGD6, CT (FGD6, KIAA1362, ZFYVE24, FYVE, RhoGEF and PH domain-containing protein 6, Zinc finger FYVE domain-containing protein 24). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FGD6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
FGD6 protein
NCBI Official Synonym Full Names
FYVE, RhoGEF and PH domain containing 6
NCBI Official Symbol
FGD6
NCBI Official Synonym Symbols
ZFYVE24
UniProt Protein Name
FYVE, RhoGEF and PH domain-containing protein 6
UniProt Synonym Protein Names
Zinc finger FYVE domain-containing protein 24
UniProt Gene Name
FGD6
UniProt Synonym Gene Names
KIAA1362; ZFYVE24
UniProt Entry Name
FGD6_HUMAN
NCBI Protein Information
FYVE, RhoGEF and PH domain-containing protein 6; zinc finger FYVE domain-containing protein 24

UniProt Comments for FGD6

FGD6: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: ruffle; Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm

Molecular Function: small GTPase binding; Rho guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity

Biological Process: regulation of cell shape; filopodium formation; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FGD6 antibody

Organs/Tissues associated with anti-FGD6 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with FGD6 and Lung
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