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KLF10 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642813

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KLF10, Monoclonal Antibody
Full Product Name
KLF10 (Krueppel-like Factor 10, EGR-alpha, Transforming Growth Factor-beta-inducible Early Growth Response Protein 1, TGFB-inducible Early Growth Response Protein 1, TIEG-1, TIEG, TIEG1)
Product Gene Name
anti-KLF10 antibody
Product Synonym Names
Anti -KLF10 (Krueppel-like Factor 10, EGR-alpha, Transforming Growth Factor-beta-inducible Early Growth Response Protein 1, TGFB-inducible Early Growth Response Protein 1, TIEG-1, TIEG, TIEG1)
Immunogen Sequence
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
4G9
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human KLF10.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
52,555 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (103661005..103668130, complement). Location: 8q22.2
OMIM
601878
3D Structure
ModBase 3D Structure for Q13118
Immunogen
Partial recombinant corresponding to aa1-110 from human KLF10 (AAH11538) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-KLF10 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-KLF10 antibody
ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-KLF10 antibody
Suitable for use in Immunofluorescence, ELISA and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-KLF10 antibody

KLF10 monoclonal antibody. Western Blot analysis of KLF10 expression in K-562.
Mouse Anti-KLF10 Monoclonal Antibody – Cat# MBS642813

Immunofluorescence (IF) of anti-KLF10 antibody

Immunofluorescence of monoclonal antibody to KLF10 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-KLF10 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS642813

Other Notes

Small volumes of anti-KLF10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLF10 purchase

MBS642813 is an antibody targeting KLF10. Also known as KLF10 (Krueppel-like Factor 10, EGR-alpha, Transforming Growth Factor-beta-inducible Early Growth Response Protein 1, TGFB-inducible Early Growth Response Protein 1, TIEG-1, TIEG, TIEG1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KLF10. It may not necessarily be applicable to this product.

NCBI GI #
73760403
NCBI GeneID
7071
NCBI Accession #
NP_001027453.1
UniProt Primary Accession #
Q13118
UniProt Secondary Accession #
O75411; Q503B2; A8MVH0; B2R794; L0R4P6; L0R679
UniProt Related Accession #
Q13118
GenBank Nucleotide #
NM_001032282.3
NCBI Official Full Name
Krueppel-like factor 10 isoform b
NCBI Official Synonym Full Names
Kruppel-like factor 10
NCBI Official Symbol
KLF10
NCBI Official Synonym Symbols
EGRA; TIEG; TIEG1; EGR-alpha
UniProt Protein Name
Krueppel-like factor 10
UniProt Synonym Protein Names
EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1
Protein Family
Krueppel-like factor
UniProt Gene Name
KLF10
UniProt Synonym Gene Names
TIEG; TIEG1; TGFB-inducible early growth response protein 1; TIEG-1
UniProt Entry Name
KLF10_HUMAN
NCBI Protein Information
Krueppel-like factor 10; early growth response-alpha; zinc finger transcription factor TIEG; TGFB-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 1

NCBI Summary for KLF10

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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UniProt Comments for KLF10

KLF10: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: nucleus

Molecular Function: protein binding; metal ion binding; transcription factor activity

Biological Process: circadian rhythm; transcription, DNA-dependent; positive regulation of osteoclast differentiation; somatic stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; cellular response to starvation; bone mineralization; negative regulation of cell proliferation; cell proliferation; cell-cell signaling; transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; skeletal development
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Research Articles on KLF10

1. KLF10 is an effective repressor of myoblast proliferation and represses FGFR1 promoter activity in these cells via an Sp1 binding site.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLF10 antibody

 Reference Product  PubMed Publications
 SP1 antibody  >18 publications with KLF10 and SP1
 TGFB1 antibody  >10 publications with KLF10 and TGFB1
 SMAD7 antibody  >9 publications with KLF10 and SMAD7
 FOXP3 antibody  >5 publications with KLF10 and FOXP3
 BMP2 antibody  >4 publications with KLF10 and BMP2
 MYCN antibody  >1 publications with KLF10 and MYCN
 FLT1 antibody  >1 publications with KLF10 and FLT1

Diseases associated with anti-KLF10 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with KLF10 and Neoplasms
 Carcinoma Antibodies  >13 publications with KLF10 and Carcinoma
 Cardiovascular Diseases Antibodies  >10 publications with KLF10 and Cardiovascular Diseases
 Inflammation Antibodies  >10 publications with KLF10 and Inflammation
 Breast Neoplasms Antibodies  >6 publications with KLF10 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >6 publications with KLF10 and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >5 publications with KLF10 and Disease Models, Animal
 Fibrosis Antibodies  >3 publications with KLF10 and Fibrosis
 Hypertrophy Antibodies  >3 publications with KLF10 and Hypertrophy
 Neoplasms, Experimental Antibodies  >3 publications with KLF10 and Neoplasms, Experimental

Organs/Tissues associated with anti-KLF10 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with KLF10 and Bone
 Blood Antibodies  >12 publications with KLF10 and Blood
 Muscle Antibodies  >7 publications with KLF10 and Muscle
 Liver Antibodies  >7 publications with KLF10 and Liver
 Brain Antibodies  >7 publications with KLF10 and Brain
 Vascular Antibodies  >6 publications with KLF10 and Vascular
 Bone Marrow Antibodies  >5 publications with KLF10 and Bone Marrow
 Pancreas Antibodies  >5 publications with KLF10 and Pancreas
 Connective Tissue Antibodies  >5 publications with KLF10 and Connective Tissue
 Lung Antibodies  >4 publications with KLF10 and Lung
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