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CACNG8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642838

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CACNG8, Polyclonal Antibody
Full Product Name
CACNG8, NT (CACNG8, CACNG6, Voltage-dependent calcium channel gamma-8 subunit, Neuronal voltage-gated calcium channel gamma-8 subunit, Transmembrane AMPAR regulatory protein gamma-8)
Product Gene Name
anti-CACNG8 antibody
Product Synonym Names
Anti -CACNG8, NT (CACNG8, CACNG6, Voltage-dependent calcium channel gamma-8 subunit, Neuronal voltage-gated calcium channel gamma-8 subunit, Transmembrane AMPAR regulatory protein gamma-8)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,313 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (54466290..54493469). Location: 19q13.4
OMIM
606900
3D Structure
ModBase 3D Structure for Q8WXS5
Immunogen
CACNG8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-127 amino acids from the N-terminal region of human CACNG8.

Product Categories/Family for anti-CACNG8 antibody

Antibodies; Abs to Transmembrane Proteins
Applications Tested/Suitable for anti-CACNG8 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CACNG8 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-CACNG8 antibody

CACNG8 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CACNG8 antibody detected the CACNG8 protein (arrow).
Rabbit Anti-CACNG8 Polyclonal Antibody – Cat# MBS642838

Immunohistochemistry (IHC) of anti-CACNG8 antibody

CACNG8 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CACNG8 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CACNG8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS642838

Other Notes

Small volumes of anti-CACNG8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNG8 purchase

MBS642838 is an antibody targeting CACNG8. Also known as CACNG8, NT (CACNG8, CACNG6, Voltage-dependent calcium channel gamma-8 subunit, Neuronal voltage-gated calcium channel gamma-8 subunit, Transmembrane AMPAR regulatory protein gamma-8). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNG8. It may not necessarily be applicable to this product.

NCBI GI #
225000720
NCBI GeneID
59283
NCBI Accession #
AAI72268.1
UniProt Primary Accession #
Q8WXS5
UniProt Secondary Accession #
Q9BXT0; Q9BY23
UniProt Related Accession #
Q8WXS5
NCBI Official Full Name
CACNG8 protein
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 8
NCBI Official Symbol
CACNG8
UniProt Protein Name
Voltage-dependent calcium channel gamma-8 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory protein gamma-8
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNG8
UniProt Synonym Gene Names
CACNG6; TARP gamma-8
UniProt Entry Name
CCG8_HUMAN
NCBI Protein Information
voltage-dependent calcium channel gamma-8 subunit; TARP gamma-8; transmembrane AMPAR regulatory protein gamma-8; neuronal voltage-gated calcium channel gamma-8 subunit

UniProt Comments for CACNG8

CACNG8: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: postsynaptic membrane; postsynaptic density; plasma membrane; voltage-gated calcium channel complex; cell junction

Molecular Function: voltage-gated calcium channel activity

Biological Process: synaptic transmission; calcium ion transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNG8 antibody

 Reference Product  PubMed Publications
 CACNG3 antibody  >1 publications with CACNG8 and CACNG3
 CACNG4 antibody  >1 publications with CACNG8 and CACNG4
 CACNG7 antibody  >1 publications with CACNG8 and CACNG7
 CACNG1 antibody  >1 publications with CACNG8 and CACNG1
 CACNG6 antibody  >1 publications with CACNG8 and CACNG6

Pathways associated with anti-CACNG8 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Organs/Tissues associated with anti-CACNG8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with CACNG8 and Brain
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