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SLC12A6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642854

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SLC12A6, Polyclonal Antibody
Full Product Name
SLC12A6, NT (SLC12A6, KCC3, Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3)
Product Gene Name
anti-SLC12A6 antibody
Product Synonym Names
Anti -SLC12A6, NT (SLC12A6, KCC3, Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
127,617 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (34522197..34630265, complement). Location: 15q13
OMIM
218000
3D Structure
ModBase 3D Structure for Q9UHW9
Immunogen
SLC12A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human SLC12A6.

Product Categories/Family for anti-SLC12A6 antibody

Antibodies; Abs to Transport Proteins
Applications Tested/Suitable for anti-SLC12A6 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SLC12A6 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-SLC12A6 antibody

Western Blot analysis in ZR-75-1 cell line lysates, using MBS642854 (35ug/lane). This demonstrates MBS642854 detected the SLC12A6 protein (arrow).
Rabbit Anti-SLC12A6 Polyclonal Antibody – Cat# MBS642854

Immunohistochemistry (IHC) of anti-SLC12A6 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS642854 for immunohistochemistry.
Rabbit Anti-SLC12A6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS642854

Other Notes

Small volumes of anti-SLC12A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC12A6 purchase

MBS642854 is an antibody targeting SLC12A6. Also known as SLC12A6, NT (SLC12A6, KCC3, Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC12A6. It may not necessarily be applicable to this product.

NCBI GI #
73909166
NCBI GeneID
9990
NCBI Accession #
AAH51744.1
UniProt Primary Accession #
Q9UHW9
UniProt Secondary Accession #
Q2VI00; Q7Z2E7; Q7Z4G5; Q8TDD4; Q9UFR2; Q9Y642; Q9Y665; A0AV76
UniProt Related Accession #
Q9UHW9
NCBI Official Full Name
SLC12A6 protein
NCBI Official Synonym Full Names
solute carrier family 12 (potassium/chloride transporter), member 6
NCBI Official Symbol
SLC12A6
NCBI Official Synonym Symbols
KCC3; ACCPN; KCC3A; KCC3B
UniProt Protein Name
Solute carrier family 12 member 6
UniProt Synonym Protein Names
Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3
Protein Family
Solute carrier family
UniProt Gene Name
SLC12A6
UniProt Synonym Gene Names
KCC3
UniProt Entry Name
S12A6_HUMAN
NCBI Protein Information
solute carrier family 12 member 6; K-Cl cotransporter 3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; potassium chloride cotransporter 3; potassium chloride cotransporter KCC3a-S3; electroneutral potassium-chloride cotransporter 3; solute carrier family 12 (potassium/chloride transporters), member 6

UniProt Comments for SLC12A6

KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: basolateral plasma membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: potassium ion transmembrane transporter activity; protein kinase binding; potassium:chloride symporter activity

Biological Process: potassium ion import; ion transport; angiogenesis; transmembrane transport; potassium ion transport

Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy
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Research Articles on SLC12A6

1. mis-trafficking of mutant protein is an important pathophysiological feature of HMSN/ACC causative KCC3 mutations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC12A6 antibody

 Reference Product  PubMed Publications
 SPG11 antibody  >1 publications with SLC12A6 and SPG11

Pathways associated with anti-SLC12A6 antibody

 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC12A6 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >20 publications with SLC12A6 and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >14 publications with SLC12A6 and Peripheral Nervous System Diseases
 Congenital Abnormalities Antibodies  >13 publications with SLC12A6 and Congenital Abnormalities
 Nervous System Malformations Antibodies  >12 publications with SLC12A6 and Nervous System Malformations
 Immune System Diseases Antibodies  >3 publications with SLC12A6 and Immune System Diseases
 Nerve Degeneration Antibodies  >3 publications with SLC12A6 and Nerve Degeneration
 Anemia Antibodies  >3 publications with SLC12A6 and Anemia
 Atrophy Antibodies  >3 publications with SLC12A6 and Atrophy
 Ataxia Antibodies  >2 publications with SLC12A6 and Ataxia
 Disease Models, Animal Antibodies  >2 publications with SLC12A6 and Disease Models, Animal

Organs/Tissues associated with anti-SLC12A6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with SLC12A6 and Brain
 Blood Antibodies  >11 publications with SLC12A6 and Blood
 Kidney Antibodies  >7 publications with SLC12A6 and Kidney
 Muscle Antibodies  >7 publications with SLC12A6 and Muscle
 Heart Antibodies  >3 publications with SLC12A6 and Heart
 Liver Antibodies  >2 publications with SLC12A6 and Liver
 Vascular Antibodies  >2 publications with SLC12A6 and Vascular
 Embryonic Tissue Antibodies  >2 publications with SLC12A6 and Embryonic Tissue
 Lung Antibodies  >2 publications with SLC12A6 and Lung
 Stomach Antibodies  >2 publications with SLC12A6 and Stomach
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