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PHLDA1 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642873

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PHLDA1, Polyclonal Antibody
Full Product Name
PHLDA1 (HRIP, TDAG51, Pleckstrin Homology-like Domain Family A Member 1, Apoptosis-associated Nuclear Protein, Proline- and Glutamine-rich Protein, Proline- and Histidine-rich Protein, T-cell Death-associated Gene 51 Protein)
Product Gene Name
anti-PHLDA1 antibody
Product Synonym Names
Anti -PHLDA1 (HRIP, TDAG51, Pleckstrin Homology-like Domain Family A Member 1, Apoptosis-associated Nuclear Protein, Proline- and Glutamine-rich Protein, Proline- and Histidine-rich Protein, T-cell Death-associated Gene 51 Protein)
Immunogen Sequence
MLESSGCKAL KEGVLEKRSD GLLQLWKKKC CILTEEGLLL IPPKQLQHQQ QQQQQQQQQQ QQPGQGPAEP SQPSGPAVAS LEPPVKLKEL HFSNMKTVDC VERKGKYMYF TVVMAEGKEI DFRCPQDQGW NAEITLQMVQ YKNRQAILAV KSTRQKQQHL VQQQPPSQPQ PQPQLQPQPQ PQPQPQPQPQ SQPQPQPQPK PQPQQLHPYP HPHPHPHSHP HSHPHPHPHP HPHQIPHPHP QPHSQPHGHR LLRSTSNSA
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PHLDA1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,016 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (76419227..76425556, complement). Location: 12q15
OMIM
605335
3D Structure
ModBase 3D Structure for Q8WV24
Immunogen
Full length human PHLDA1, aa1-259 (AAH18929.3).

Product Categories/Family for anti-PHLDA1 antibody

Antibodies; Abs to Pleckstrin Homology Proteins
Applications Tested/Suitable for anti-PHLDA1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PHLDA1 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-PHLDA1 antibody

Western Blot analysis of PHLDA1 expression in transfected 293T cell line by PHLDA1 polyclonal antibody. Lane 1: PHLDA1 transfected lysate (28.49kD). Lane 2: Non-transfected lysate.
Mouse Anti-PHLDA1 Polyclonal Antibody – Cat# MBS642873

Immunofluorescence (IF) of anti-PHLDA1 antibody

Immunofluorescence of purified antibody to PHLDA1 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-PHLDA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS642873

Other Notes

Small volumes of anti-PHLDA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHLDA1 purchase

MBS642873 is an antibody targeting PHLDA1. Also known as PHLDA1 (HRIP, TDAG51, Pleckstrin Homology-like Domain Family A Member 1, Apoptosis-associated Nuclear Protein, Proline- and Glutamine-rich Protein, Proline- and Histidine-rich Protein, T-cell Death-associated Gene 51 Protein). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PHLDA1. It may not necessarily be applicable to this product.

NCBI GI #
83977459
NCBI GeneID
22822
NCBI Accession #
NP_031376.3
UniProt Primary Accession #
Q8WV24
UniProt Secondary Accession #
Q15184; Q2TAN2; Q9NZ17; A1A4G9
UniProt Related Accession #
Q8WV24
GenBank Nucleotide #
NM_007350.3
NCBI Official Full Name
pleckstrin homology-like domain family A member 1
NCBI Official Synonym Full Names
pleckstrin homology-like domain, family A, member 1
NCBI Official Symbol
PHLDA1
NCBI Official Synonym Symbols
PHRIP; TDAG51; DT1P1B11
UniProt Protein Name
Pleckstrin homology-like domain family A member 1
UniProt Synonym Protein Names
Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; Proline- and histidine-rich protein; T-cell death-associated gene 51 protein
Protein Family
Pleckstrin homology-like domain family
UniProt Gene Name
PHLDA1
UniProt Synonym Gene Names
PHRIP; TDAG51; PQ-rich protein; PQR protein
UniProt Entry Name
PHLA1_HUMAN
NCBI Protein Information
pleckstrin homology-like domain family A member 1; PQR protein; PQ-rich protein; proline-histidine rich protein; proline- and glutamine-rich protein; proline- and histidine-rich protein; apoptosis-associated nuclear protein; T-cell death-associated gene 51 protein

UniProt Comments for PHLDA1

PHLDA1: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

Protein type: Nucleolus; Apoptosis

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; cytoplasmic vesicle membrane; nucleolus; plasma membrane

Molecular Function: protein binding

Biological Process: apoptosis; positive regulation of apoptosis; forebrain neuron differentiation; FasL biosynthetic process
Show more

Research Articles on PHLDA1

1. PHLDA1 differentiates between desmoplastic trichoepithelioma and morpheaform basal cell carcinoma but shows variable staining in microcystic adnexal carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHLDA1 antibody

 Reference Product  PubMed Publications
 IGF1 antibody  >2 publications with PHLDA1 and IGF1

Diseases associated with anti-PHLDA1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with PHLDA1 and Neoplasms
 Carcinoma Antibodies  >14 publications with PHLDA1 and Carcinoma
 Breast Neoplasms Antibodies  >5 publications with PHLDA1 and Breast Neoplasms
 Inflammation Antibodies  >5 publications with PHLDA1 and Inflammation
 Nervous System Diseases Antibodies  >4 publications with PHLDA1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with PHLDA1 and Cardiovascular Diseases
 Fibrosis Antibodies  >2 publications with PHLDA1 and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with PHLDA1 and Cell Transformation, Neoplastic
 Melanoma Antibodies  >2 publications with PHLDA1 and Melanoma
 Carcinoma, Squamous Cell Antibodies  >2 publications with PHLDA1 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-PHLDA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >12 publications with PHLDA1 and Skin
 Blood Antibodies  >11 publications with PHLDA1 and Blood
 Embryonic Tissue Antibodies  >5 publications with PHLDA1 and Embryonic Tissue
 Kidney Antibodies  >3 publications with PHLDA1 and Kidney
 Bone Antibodies  >3 publications with PHLDA1 and Bone
 Mammary Gland Antibodies  >3 publications with PHLDA1 and Mammary Gland
 Brain Antibodies  >3 publications with PHLDA1 and Brain
 Intestine Antibodies  >2 publications with PHLDA1 and Intestine
 Heart Antibodies  >2 publications with PHLDA1 and Heart
 Liver Antibodies  >2 publications with PHLDA1 and Liver
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