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INSRR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642982

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Insrr, Polyclonal Antibody
Full Product Name
Insrr, CT (Insrr, Irr, Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain)
Product Gene Name
anti-INSRR antibody
Product Synonym Names
Anti -Insrr, CT (Insrr, Irr, Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
143,720 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (156810665..156828712, complement). Location: 1q21-q23
OMIM
147671
3D Structure
ModBase 3D Structure for P14616
Immunogen
Mouse Insrr antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1227-1255 amino acids from the C-terminal region of Mouse Insrr.

Product Categories/Family for anti-INSRR antibody

Antibodies; Abs to Insulin
Applications Tested/Suitable for anti-INSRR antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-INSRR antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-INSRR antibody

Mouse Insrr Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the Insrr antibody detected the Insrr protein (arrow).
Rabbit Anti-INSRR Polyclonal Antibody – Cat# MBS642982

Western Blot (WB) of anti-INSRR antibody

Mouse Insrr Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Insrr antibody detected the Insrr protein (arrow).
Rabbit Anti-INSRR Polyclonal Antibody, Western Blot (WB) – Cat# MBS642982

Other Notes

Small volumes of anti-INSRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INSRR purchase

MBS642982 is an antibody targeting INSRR. Also known as Insrr, CT (Insrr, Irr, Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INSRR. It may not necessarily be applicable to this product.

NCBI GI #
31657140
NCBI GeneID
3645
NCBI Accession #
NP_055030.1
UniProt Primary Accession #
P14616
UniProt Secondary Accession #
O60724; Q5VZS3
UniProt Related Accession #
P14616
GenBank Nucleotide #
NM_014215.2
NCBI Official Full Name
insulin receptor-related protein
NCBI Official Synonym Full Names
insulin receptor-related receptor
NCBI Official Symbol
INSRR
NCBI Official Synonym Symbols
IRR
UniProt Protein Name
Insulin receptor-related protein
UniProt Synonym Protein Names
IR-related receptor
Protein Family
Insulin receptor-related protein
UniProt Gene Name
INSRR
UniProt Synonym Gene Names
IRR; IRR
UniProt Entry Name
INSRR_HUMAN
NCBI Protein Information
insulin receptor-related protein; IR-related receptor

UniProt Comments for INSRR

IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; InsR family

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway
Show more

Research Articles on INSRR

1. Analysis of structural determinants of alkali sensor IRR positive cooperativity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-INSRR antibody

 Reference Product  PubMed Publications
 GRB2 antibody  >1 publications with INSRR and GRB2

Pathways associated with anti-INSRR antibody

 Products by Pathway  Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with anti-INSRR antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3 publications with INSRR and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with INSRR and Liver Neoplasms
 Brain Diseases Antibodies  >1 publications with INSRR and Brain Diseases
 Disease Models, Animal Antibodies  >1 publications with INSRR and Disease Models, Animal
 Hyperplasia Antibodies  >1 publications with INSRR and Hyperplasia
 Carcinoma, Adenoid Cystic Antibodies  >1 publications with INSRR and Carcinoma, Adenoid Cystic

Organs/Tissues associated with anti-INSRR antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >19 publications with INSRR and Kidney
 Brain Antibodies  >13 publications with INSRR and Brain
 Testis Antibodies  >2 publications with INSRR and Testis
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