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SLC12A2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642992

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. More details

$785 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SLC12A2, Polyclonal Antibody
Full Product Name
SLC12A2 (Solute Carrier Family 12 Member 2, Bumetanide-sensitive Sodium-(potassium)-chloride Cotransporter 1, NKCC1)
Product Gene Name
anti-SLC12A2 antibody
Product Synonym Names
Anti -SLC12A2 (Solute Carrier Family 12 Member 2, Bumetanide-sensitive Sodium-(potassium)-chloride Cotransporter 1, NKCC1)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.1% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SLC12A2/NKCC1. Species sequence homology: Gorilla (100%), gibbon (89%), monkey, marmoset, ferret, canine, Panda (84%).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
131,447 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (127419483..127525380). Location: 5q23.3
OMIM
600840
3D Structure
ModBase 3D Structure for P55011
Immunogen
Synthetic peptide corresponding to 19aa from human SLC12A2/NKCC1 at N-Terminal.

Product Categories/Family for anti-SLC12A2 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SLC12A2 antibody
Immunohistochemistry (IHC)
Application Notes for anti-SLC12A2 antibody
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (Paraffin): 7.5-10ug/ml

Immunohistochemistry (IHC) of anti-SLC12A2 antibody

SLC12A2/NKCC1 was used in IHC to stain formalin-fixed, paraffin- embedded human stomach, followed by biotinylated goat, rabbit IgG, alkaline phosphatase-streptavidin and chromogen.
Rabbit Anti-SLC12A2 Polyclonal Antibody – Cat# MBS642992

Immunohistochemistry (IHC) of anti-SLC12A2 antibody

SLC12A2/NKCC1 was used in IHC to stain formalin-fixed, paraffin- embedded human prostate, followed by biotinylated goat, rabbit IgG, alkaline phosphatase-streptavidin and chromogen.
Rabbit Anti-SLC12A2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS642992

Other Notes

Small volumes of anti-SLC12A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC12A2 purchase

MBS642992 is an antibody targeting SLC12A2. Also known as SLC12A2 (Solute Carrier Family 12 Member 2, Bumetanide-sensitive Sodium-(potassium)-chloride Cotransporter 1, NKCC1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC12A2. It may not necessarily be applicable to this product.

NCBI GI #
374253823
NCBI GeneID
6558
NCBI Accession #
NP_001243390.1
UniProt Primary Accession #
P55011
UniProt Secondary Accession #
Q8N713; Q8WWH7
UniProt Related Accession #
P55011
GenBank Nucleotide #
NM_001256461.1
NCBI Official Full Name
solute carrier family 12 member 2 isoform 2
NCBI Official Synonym Full Names
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
NCBI Official Symbol
SLC12A2
NCBI Official Synonym Symbols
BSC; BSC2; NKCC1
UniProt Protein Name
Solute carrier family 12 member 2
UniProt Synonym Protein Names
Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
Protein Family
Solute carrier family
UniProt Gene Name
SLC12A2
UniProt Synonym Gene Names
NKCC1
UniProt Entry Name
S12A2_HUMAN
NCBI Protein Information
solute carrier family 12 member 2; basolateral Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 2

NCBI Summary for SLC12A2

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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UniProt Comments for SLC12A2

NKCC1: a multi-pass membrane cation transporter protein. Aids transcellular movement of chloride across both secretory and absorptive epithelia. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Expressed in many tissues. Bumetanide is a potent NKCC1 antagonist. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q23.3

Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; vesicle

Molecular Function: protein binding; ammonium transmembrane transporter activity; sodium:potassium:chloride symporter activity

Biological Process: hyperosmotic response; transport; multicellular organism growth; transepithelial chloride transport; sodium ion transport; ion transport; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of cell volume; transmembrane transport; potassium ion transport; ammonium transport; gamma-aminobutyric acid signaling pathway
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Research Articles on SLC12A2

1. The results indicate a role for COMMD1 in the regulation of NKCC1 membrane expression and ubiquitination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC12A2 antibody

 Reference Product  PubMed Publications
 KCNQ1 antibody  >5 publications with SLC12A2 and KCNQ1

Pathways associated with anti-SLC12A2 antibody

 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram

Diseases associated with anti-SLC12A2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with SLC12A2 and Nervous System Diseases
 Kidney Diseases Antibodies  >2 publications with SLC12A2 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with SLC12A2 and Disease Models, Animal
 Hypertension Antibodies  >2 publications with SLC12A2 and Hypertension
 Infertility, Male Antibodies  >1 publications with SLC12A2 and Infertility, Male
 Memory Disorders Antibodies  >1 publications with SLC12A2 and Memory Disorders
 Weight Loss Antibodies  >1 publications with SLC12A2 and Weight Loss
 Cognition Disorders Antibodies  >1 publications with SLC12A2 and Cognition Disorders
 Inflammation Antibodies  >1 publications with SLC12A2 and Inflammation
 Movement Disorders Antibodies  >1 publications with SLC12A2 and Movement Disorders

Organs/Tissues associated with anti-SLC12A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with SLC12A2 and Brain
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