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FMOD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643103

Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
FMOD, Polyclonal Antibody
Full Product Name
FMOD, CT (FMOD, FM, SLRR2E, Fibromodulin, Collagen-binding 59kD protein, Keratan sulfate proteoglycan fibromodulin)
Product Gene Name
anti-FMOD antibody
Product Synonym Names
Anti -FMOD, CT (FMOD, FM, SLRR2E, Fibromodulin, Collagen-binding 59kD protein, Keratan sulfate proteoglycan fibromodulin)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,179 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (203309749..203320557, complement). Location: 1q32
OMIM
600245
3D Structure
ModBase 3D Structure for Q06828
Immunogen
FMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343~373 amino acids from the C-terminal region of human FMOD.

Product Categories/Family for anti-FMOD antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-FMOD antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-FMOD antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-FMOD antibody

Western Blot analysis in mouse cerebellum tissue lysates (35ug/lane) using MBS643103. FMOD (arrow) was detected using MBS643103.
Rabbit Anti-FMOD Polyclonal Antibody – Cat# MBS643103

Immunohistochemistry (IHC) of anti-FMOD antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human brain tissue reacted with MBS643103, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Rabbit Anti-FMOD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS643103

Flow Cytometry (FC/FACS) of anti-FMOD antibody

Flow Cytometric analysis of HeLa cells using MBS643103 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FMOD Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS643103

Other Notes

Small volumes of anti-FMOD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FMOD purchase

MBS643103 is an antibody targeting FMOD. Also known as FMOD, CT (FMOD, FM, SLRR2E, Fibromodulin, Collagen-binding 59kD protein, Keratan sulfate proteoglycan fibromodulin). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FMOD. It may not necessarily be applicable to this product.

NCBI GI #
71040111
NCBI GeneID
2331
NCBI Accession #
NP_002014.2
UniProt Primary Accession #
Q06828
UniProt Secondary Accession #
Q15331; Q8IV47
UniProt Related Accession #
Q06828
GenBank Nucleotide #
NM_002023.4
NCBI Official Full Name
fibromodulin
NCBI Official Synonym Full Names
fibromodulin
NCBI Official Symbol
FMOD
NCBI Official Synonym Symbols
FM; SLRR2E
UniProt Protein Name
Fibromodulin
UniProt Synonym Protein Names
Collagen-binding 59 kDa protein; Keratan sulfate proteoglycan fibromodulin
Protein Family
Fibromodulin
UniProt Gene Name
FMOD
UniProt Synonym Gene Names
FM; SLRR2E; FM
UniProt Entry Name
FMOD_HUMAN
NCBI Protein Information
fibromodulin; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate proteoglycan fibromodulin

NCBI Summary for FMOD

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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UniProt Comments for FMOD

FMOD: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; lysosomal lumen; Golgi lumen; extracellular region

Biological Process: keratan sulfate metabolic process; transforming growth factor beta receptor complex assembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process
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Research Articles on FMOD

1. Associations between higher fibomodulin gene expression and risk factors in chronic lymphocytic leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FMOD antibody

 Reference Product  PubMed Publications
 LUM antibody  >8 publications with FMOD and LUM
 PRELP antibody  >4 publications with FMOD and PRELP
 ACAN antibody  >3 publications with FMOD and ACAN
 KERA antibody  >1 publications with FMOD and KERA

Pathways associated with anti-FMOD antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram

Diseases associated with anti-FMOD antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with FMOD and Neoplasms
 Fibrosis Antibodies  >2 publications with FMOD and Fibrosis
 Liver Diseases Antibodies  >1 publications with FMOD and Liver Diseases
 Urination Disorders Antibodies  >1 publications with FMOD and Urination Disorders
 Pain Antibodies  >1 publications with FMOD and Pain
 Nervous System Diseases Antibodies  >1 publications with FMOD and Nervous System Diseases
 Hypertension Antibodies  >1 publications with FMOD and Hypertension
 Cardiovascular Diseases Antibodies  >1 publications with FMOD and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with FMOD and Hyperplasia
 Drug-Induced Liver Injury Antibodies  >1 publications with FMOD and Drug-Induced Liver Injury

Organs/Tissues associated with anti-FMOD antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >18 publications with FMOD and Bone
 Connective Tissue Antibodies  >13 publications with FMOD and Connective Tissue
 Blood Antibodies  >9 publications with FMOD and Blood
 Eye Antibodies  >6 publications with FMOD and Eye
 Brain Antibodies  >4 publications with FMOD and Brain
 Vascular Antibodies  >4 publications with FMOD and Vascular
 Embryonic Tissue Antibodies  >4 publications with FMOD and Embryonic Tissue
 Skin Antibodies  >3 publications with FMOD and Skin
 Mouth Antibodies  >3 publications with FMOD and Mouth
 Muscle Antibodies  >3 publications with FMOD and Muscle
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