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NCAPD2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643190

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I… More details

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Product Overview

Online Datasheet in PDF
Product Name
NCAPD2, Monoclonal Antibody
Full Product Name
NCAPD2 (CAPD2, CNAP1, KIAA0159, Condensin Complex Subunit 1, Chromosome Condensation-related SMC-associated Protein 1, Chromosome-associated Protein D2, hCAP-D2, Non-SMC Condensin I Complex Subunit D2, XCAP-D2 Homolog)
Product Gene Name
anti-NCAPD2 antibody
Product Synonym Names
Anti -NCAPD2 (CAPD2, CNAP1, KIAA0159, Condensin Complex Subunit 1, Chromosome Condensation-related SMC-associated Protein 1, Chromosome-associated Protein D2, hCAP-D2, Non-SMC Condensin I Complex Subunit D2, XCAP-D2 Homolog)
Immunogen Sequence
LRKMLDNFDC FGDKLSDESI FSAFLSVVGK LRRGAKPEGK AIIDEFEQKL RACHTRGLDG IKELEIGQAG SQRAPSAKKP SSGSRYQPLA STASDNDFVT
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
4C12
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CNAP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
157,182 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (6602547..6641132). Location: 12p13.3
3D Structure
ModBase 3D Structure for Q15021
Immunogen
Partial recombinant corresponding to aa1240-1339 from CNAP1 (AAH28182) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-NCAPD2 antibody

Antibodies; Abs to Nuclear Proteins
Applications Tested/Suitable for anti-NCAPD2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-NCAPD2 antibody
Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-NCAPD2 antibody

Western Blot detection against Immunogen (36.63kD.
Mouse Anti-NCAPD2 Monoclonal Antibody – Cat# MBS643190

Western Blot (WB) of anti-NCAPD2 antibody

CNAP1 monoclonal antibody Western Blot analysis of CNAP1 expression in HeLa.
Mouse Anti-NCAPD2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS643190

Immunohistochemistry (IHC) of anti-NCAPD2 antibody

Immunoperoxidase of monoclonal antibody to CNAP1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3ug/ml]
Mouse Anti-NCAPD2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS643190

Immunofluorescence (IF) of anti-NCAPD2 antibody

Immunofluorescence of monoclonal antibody to CNAP1 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-NCAPD2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS643190

Testing Data of anti-NCAPD2 antibody

Detection limit for recombinant GST tagged CNAP1 is ~0.1ng/ml as a capture antibody.
Mouse Anti-NCAPD2 Monoclonal Antibody, Testing Data – Cat# MBS643190

Other Notes

Small volumes of anti-NCAPD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCAPD2 purchase

MBS643190 is an antibody targeting NCAPD2. Also known as NCAPD2 (CAPD2, CNAP1, KIAA0159, Condensin Complex Subunit 1, Chromosome Condensation-related SMC-associated Protein 1, Chromosome-associated Protein D2, hCAP-D2, Non-SMC Condensin I Complex Subunit D2, XCAP-D2 Homolog). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NCAPD2. It may not necessarily be applicable to this product.

NCBI GI #
118142821
NCBI GeneID
9918
NCBI Accession #
AAH16913.1
UniProt Primary Accession #
Q15021
UniProt Secondary Accession #
Q8N6U3; D3DUR4
UniProt Related Accession #
Q15021
NCBI Official Full Name
NCAPD2 protein
NCBI Official Synonym Full Names
non-SMC condensin I complex, subunit D2
NCBI Official Symbol
NCAPD2
NCBI Official Synonym Symbols
CNAP1; CAP-D2; hCAP-D2
UniProt Protein Name
Condensin complex subunit 1
UniProt Synonym Protein Names
Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; hCAP-D2; Non-SMC condensin I complex subunit D2; XCAP-D2 homolog
Protein Family
Condensin complex
UniProt Gene Name
NCAPD2
UniProt Synonym Gene Names
CAPD2; CNAP1; KIAA0159; hCAP-D2
UniProt Entry Name
CND1_HUMAN
NCBI Protein Information
condensin complex subunit 1; XCAP-D2 homolog; chromosome-associated protein D2; chromosome condensation related SMC associated protein 1; chromosome condensation-related SMC-associated protein 1

UniProt Comments for NCAPD2

CNAP1: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. Belongs to the CND1 (condensin subunit 1) family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: nucleoplasm; nuclear chromosome; membrane; pronucleus; cytoplasm; condensin complex; condensin core heterodimer; condensed chromosome; nucleus; cytosol

Molecular Function: protein binding; histone binding

Biological Process: cell division; mitotic chromosome condensation; mitotic cell cycle
Show more

Research Articles on NCAPD2

1. Data show that that DNA repear process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NCAPD2 antibody

 Reference Product  PubMed Publications
 NCAPH antibody  >1 publications with NCAPD2 and NCAPH
 NCAPG antibody  >1 publications with NCAPD2 and NCAPG

Pathways associated with anti-NCAPD2 antibody

 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prometaphase Chromosomes Pathway antibodies  Condensation Of Prometaphase Chromosomes Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram

Diseases associated with anti-NCAPD2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with NCAPD2 and Nervous System Diseases
 Ovarian Neoplasms Antibodies  >1 publications with NCAPD2 and Ovarian Neoplasms
 Neoplasms Antibodies  >1 publications with NCAPD2 and Neoplasms
 Ovarian Diseases Antibodies  >1 publications with NCAPD2 and Ovarian Diseases
 Adenocarcinoma Antibodies  >1 publications with NCAPD2 and Adenocarcinoma
 Inflammation Antibodies  >1 publications with NCAPD2 and Inflammation

Organs/Tissues associated with anti-NCAPD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with NCAPD2 and Muscle
 Liver Antibodies  >1 publications with NCAPD2 and Liver
 Eye Antibodies  >1 publications with NCAPD2 and Eye
 Brain Antibodies  >1 publications with NCAPD2 and Brain
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