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KMT2B Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643382

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal… More details

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Product Overview

Online Datasheet in PDF
Product Name
MLL4 (KMT2B), Polyclonal Antibody
Full Product Name
MLL4, CT (Histone-lysine N-methyltransferase MLL4, KIAA0304, Myeloid/Lymphoid or Mixed-lineage Leukemia Protein 4, WW Domain-binding Protein 7, WBP-7, Trithorax Homolog 2, Lysine N-methyltransferase 2D, KMT2D, HRX2, KMT2D, MLL2, MLL4, TRX2, WBP7)
Product Gene Name
anti-KMT2B antibody
Product Synonym Names
Anti -MLL4, CT (Histone-lysine N-methyltransferase MLL4, KIAA0304, Myeloid/Lymphoid or Mixed-lineage Leukemia Protein 4, WW Domain-binding Protein 7, WBP-7, Trithorax Homolog 2, Lysine N-methyltransferase 2D, KMT2D, HRX2, KMT2D, MLL2, MLL4, TRX2, WBP7)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human MLL4. Species sequence homology: Mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
293,515 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (36208921..36229781). Location: 19q13.1
OMIM
606834
3D Structure
ModBase 3D Structure for Q9UMN6
Immunogen
Synthetic peptide corresponding to CNCGAKRCRRFLN of human MLL4 at C-terminal.

Product Categories/Family for anti-KMT2B antibody

Antibodies; Abs to Enzymes; Methyltransferase
Applications Tested/Suitable for anti-KMT2B antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-KMT2B antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:128,000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-KMT2B antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with MLL4 antibody followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Goat Anti-KMT2B Polyclonal Antibody – Cat# MBS643382

Immunohistochemistry (IHC) of anti-KMT2B antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with MLL4 antibody followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Goat Anti-KMT2B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS643382

Other Notes

Small volumes of anti-KMT2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KMT2B purchase

MBS643382 is an antibody targeting KMT2B. Also known as MLL4, CT (Histone-lysine N-methyltransferase MLL4, KIAA0304, Myeloid/Lymphoid or Mixed-lineage Leukemia Protein 4, WW Domain-binding Protein 7, WBP-7, Trithorax Homolog 2, Lysine N-methyltransferase 2D, KMT2D, HRX2, KMT2D, MLL2, MLL4, TRX2, WBP7). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for KMT2B. It may not necessarily be applicable to this product.

NCBI GI #
211828317
NCBI GeneID
9757
NCBI Accession #
AAH07353.3
UniProt Primary Accession #
Q9UMN6
UniProt Secondary Accession #
O15022; O95836; Q96GP2; Q96IP3; Q9UK25; Q9Y668; Q9Y669
UniProt Related Accession #
Q9UMN6
NCBI Official Full Name
MLL4 protein
NCBI Official Synonym Full Names
lysine (K)-specific methyltransferase 2B
NCBI Official Symbol
KMT2B
NCBI Official Synonym Symbols
HRX2; MLL2; MLL4; TRX2; WBP7; MLL1B
UniProt Protein Name
Histone-lysine N-methyltransferase 2B
UniProt Synonym Protein Names
Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
KMT2B
UniProt Synonym Gene Names
HRX2; KIAA0304; MLL2; MLL4; TRX2; WBP7; Lysine N-methyltransferase 2B; WBP-7
UniProt Entry Name
KMT2B_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase 2B; KMT2D; WBP-7; trithorax homolog 2; trithorax homologue 2; WW domain binding protein 7; WW domain-binding protein 7; lysine N-methyltransferase 2D; mixed lineage leukemia gene homolog 2; histone-lysine N-methyltransferase MLL4; myeloid/lymphoid or mixed-lineage leukemia 4; myeloid/lymphoid or mixed-lineage leukemia protein 4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4

UniProt Comments for KMT2B

MLL2: may be a transcriptional regulator. Contains 3 A.T hook DNA-binding domains. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; Methyltransferase, protein lysine; EC 2.1.1.43; DNA-binding; Methyltransferase

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription factor activity

Biological Process: ovulation; establishment and/or maintenance of chromatin architecture; ovarian follicle development; transcription, DNA-dependent; chromatin-mediated maintenance of transcription; histone H3-K4 methylation; regulation of histone H3-K4 methylation; oocyte differentiation; gene silencing
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Research Articles on KMT2B

1. KMT2B transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KMT2B antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-KMT2B antibody

 Disease Name  Pubmed Publications
 Leukemia, Myeloid Antibodies  >2 publications with KMT2B and Leukemia, Myeloid

Organs/Tissues associated with anti-KMT2B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with KMT2B and Brain
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