Thymosin B4 (TMSB4X) Antibody – Sheep Polyclonal

Thymosin beta 4 is a 5kD member of the B-thymosin family of molecules. Members of this family range from 41-44aa in length, and possess an isoelectric point that lies between pH 4.0-7.0 a-thymosins have values less than 4.0. Multiple cell types produce TB4, either constitutively, or after stimulation. They include platelets, endothelial cells, neutrophils, astrocytes and macrophages. TB4 is both a secreted and intracellular molecule. The secreted form contributes to wound healing and angiogenesis, and may act on ATPase. Intracellularly, it forms a 1:1 complex with G-actin and blocks F-actin polymerization. This regulates the availablility of actin monomers for filament formation and subsequent cell migration. Mature human TB4 is 43aa in length aa2-44. It contains an actin-binding site aa17-23, one acetylated Ser and five acetylated lysines (4; 12; 26; 32; 39) and one phosphorylation site at Thr23. TB4 undergoes proteolytic processing to generate an N-terminal acetylated peptide aa2-5: SerAspLysPro. Mature human TB4 is identical to mouse TB14 in aa sequence, and it shares 74% aa identity with its human family member TB10.

Small volumes of anti-TMSB4X antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS643388 is an antibody targeting TMSB4X. Also known as Thymosin b4 (TMSB4X, Thymosin beta-4, T beta-4, Fx, TB4X, THYB4, TMSB4). Reactive in Human. Host: Sheep.