Rabbit Anti-PPP1R9B Polyclonal Antibody – Cat# MBS643448

PPP1R9B Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the PPP1R9B antibody detected the PPP1R9B protein (arrow).

PPP1R9B Antibody – Rabbit Polyclonal

Name: PPP1R9B Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS643448
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643448

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PPP1R9B, Polyclonal Antibody

Full Product Name

PPP1R9B, NT (PPP1R9B, PPP1R6, Neurabin-2, Protein phosphatase 1 regulatory subunit 9B, Spinophilin, Neurabin-II)

Product Gene Name

anti-PPP1R9B antibody

Product Synonym Names

Anti -PPP1R9B, NT (PPP1R9B, PPP1R6, Neurabin-2, Protein phosphatase 1 regulatory subunit 9B, Spinophilin, Neurabin-II)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

89,192 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (48211101..48227877, complement). Location: 17q21.33

OMIM

603325

3D Structure

ModBase 3D Structure for Q96SB3

Immunogen

PPP1R9B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PPP1R9B.

Product Categories/Family for anti-PPP1R9B antibody

Antibodies; Abs to Enzymes; Phosphatase

Applications Tested/Suitable for anti-PPP1R9B antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-PPP1R9B antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-PPP1R9B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R9B purchase

MBS643448 is an antibody targeting PPP1R9B. Also known as PPP1R9B, NT (PPP1R9B, PPP1R6, Neurabin-2, Protein phosphatase 1 regulatory subunit 9B, Spinophilin, Neurabin-II). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R9B. It may not necessarily be applicable to this product.

NCBI GI #

16740571

NCBI GeneID

84687

NCBI Accession #

AAH16162.1

UniProt Primary Accession #

Q96SB3

UniProt Secondary Accession #

Q8TCR9

UniProt Related Accession #

Q96SB3

NCBI Official Full Name

PPP1R9B protein

NCBI Official Synonym Full Names

protein phosphatase 1, regulatory subunit 9B

NCBI Official Symbol

PPP1R9B

NCBI Official Synonym Symbols

Spn; SPINO; PPP1R6; PPP1R9

UniProt Protein Name

Neurabin-2

UniProt Synonym Protein Names

Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin

Protein Family

Neurabin

UniProt Gene Name

PPP1R9B

UniProt Synonym Gene Names

PPP1R6

UniProt Entry Name

NEB2_HUMAN

NCBI Protein Information

neurabin-2; neurabin II; neurabin-II; spinophilin; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin

UniProt Comments for PPP1R9B

Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.

Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: nucleoplasm; cortical actin cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; protein phosphatase type 1 complex; filopodium

Molecular Function: protein binding; protein phosphatase inhibitor activity; actin binding; protein phosphatase 1 binding

Biological Process: regulation of synaptic transmission; regulation of cell growth by extracellular stimulus; regulation of protein amino acid phosphorylation; cell migration; filopodium formation; RNA splicing; calcium-mediated signaling; regulation of exit from mitosis; actin filament organization; regulation of cell proliferation; negative regulation of catalytic activity; dendrite development; negative regulation of cell growth; cell cycle arrest

Research Articles on PPP1R9B

1. study found a substantial number of hepatocellular carcinomas (HCC) show reduced or absent Spn expression; the low expression of Spn in tumour tissue is an independent negative prognostic factor for clinical outcome in HCC; spinophilin expression inversely correlates with proliferative activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP1R9B antibody

Reference Product	PubMed Publications
PPP1CA antibody	>1 publications with PPP1R9B and PPP1CA

Diseases associated with anti-PPP1R9B antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>3 publications with PPP1R9B and Congenital Abnormalities
Neoplasms Antibodies	>2 publications with PPP1R9B and Neoplasms
Cognition Disorders Antibodies	>2 publications with PPP1R9B and Cognition Disorders
Necrosis Antibodies	>1 publications with PPP1R9B and Necrosis
Schizophrenia Antibodies	>1 publications with PPP1R9B and Schizophrenia
Neoplasms, Experimental Antibodies	>1 publications with PPP1R9B and Neoplasms, Experimental
Mammary Neoplasms, Animal Antibodies	>1 publications with PPP1R9B and Mammary Neoplasms, Animal
Nervous System Malformations Antibodies	>1 publications with PPP1R9B and Nervous System Malformations
Musculoskeletal Abnormalities Antibodies	>1 publications with PPP1R9B and Musculoskeletal Abnormalities
Sinusitis Antibodies	>1 publications with PPP1R9B and Sinusitis

Organs/Tissues associated with anti-PPP1R9B antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with PPP1R9B and Brain
Connective Tissue Antibodies	>1 publications with PPP1R9B and Connective Tissue
Bone Antibodies	>1 publications with PPP1R9B and Bone
Intestine Antibodies	>1 publications with PPP1R9B and Intestine
Eye Antibodies	>1 publications with PPP1R9B and Eye
Blood Antibodies	>1 publications with PPP1R9B and Blood
Lung Antibodies	>1 publications with PPP1R9B and Lung