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STAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643460

MBS643460 is an antibody targeting STAP1. Also known as STAP1 (Signal-transducing Adaptor Protein 1, STAP-1, BCR Downstream-signaling Protein 1, BRDG1, Docking Protein BRDG1, Stem Cell Adaptor Protein 1). Reactive in Human, Mouse. Host: Rabbit. More details

$970 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STAP1, Polyclonal Antibody
Full Product Name
STAP1 (Signal-transducing Adaptor Protein 1, STAP-1, BCR Downstream-signaling Protein 1, BRDG1, Docking Protein BRDG1, Stem Cell Adaptor Protein 1)
Product Gene Name
anti-STAP1 antibody
Product Synonym Names
Anti -STAP1 (Signal-transducing Adaptor Protein 1, STAP-1, BCR Downstream-signaling Protein 1, BRDG1, Docking Protein BRDG1, Stem Cell Adaptor Protein 1)
Immunogen Sequence
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human STAP1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,291 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (68424415..68473059). Location: 4q13.2
OMIM
604298
3D Structure
ModBase 3D Structure for Q9ULZ2
Immunogen
Full length human STAP1, aa1-295 (NP_036240.1).

Product Categories/Family for anti-STAP1 antibody

Antibodies; Abs to Adapter Proteins
Applications Tested/Suitable for anti-STAP1 antibody
Western Blot (WB)
Application Notes for anti-STAP1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-STAP1 antibody

STAP1 rabbit polyclonal antibody. Western Blot analysis of STAP1 expression in human kidney.
Rabbit Anti-STAP1 Polyclonal Antibody – Cat# MBS643460

Western Blot (WB) of anti-STAP1 antibody

STAP1 rabbit polyclonal antibody. Western Blot analysis of STAP1 expression in mouse intestine.
Rabbit Anti-STAP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS643460

Western Blot (WB) of anti-STAP1 antibody

Western Blot analysis of STAP1 expression in transfected 293T cell line by STAP1 polyclonal antibody. Lane 1: STAP1 transfected lysate (34.3kD). Lane 2: Non-transfected lysate.
Rabbit Anti-STAP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS643460

Other Notes

Small volumes of anti-STAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAP1. It may not necessarily be applicable to this product.

NCBI GI #
15928990
NCBI GeneID
26228
NCBI Accession #
AAH14958.1
UniProt Primary Accession #
Q9ULZ2
UniProt Secondary Accession #
B2R980
UniProt Related Accession #
Q9ULZ2
NCBI Official Full Name
STAP1 protein
NCBI Official Synonym Full Names
signal transducing adaptor family member 1
NCBI Official Symbol
STAP1
NCBI Official Synonym Symbols
BRDG1; STAP-1
UniProt Protein Name
Signal-transducing adaptor protein 1
UniProt Synonym Protein Names
BCR downstream-signaling protein 1; Docking protein BRDG1; Stem cell adaptor protein 1
Protein Family
Signal-transducing adaptor protein
UniProt Gene Name
STAP1
UniProt Synonym Gene Names
BRDG1; STAP-1
UniProt Entry Name
STAP1_HUMAN
NCBI Protein Information
signal-transducing adaptor protein 1; docking protein BRDG1; BCR downstream signaling 1; stem cell adaptor protein 1; BCR downstream-signaling protein 1; signal-transducing adaptor protein-1

NCBI Summary for STAP1

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for STAP1

STAP1: an adaptor protein which contains pleckstrin homology (PH) and Src homology 2-like (SRC) domains and a proline-rich region. Induced in activated bone marrow-derived macrophages, and by CpG, LPS, and interferon in myeloid cell lines. Induces pro-inflammatory responses and may contribute to neuronal apoptosis and degeneration. Overexpressed, it interacts with the CSFR, inhibiting its ligand-dependent phosphorylation. Its expression inhibits cellular migration and can increase cytotoxicity against 661W photoreceptor like cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: intracellular protein transport; positive regulation of signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on STAP1

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAP1 antibody

 Reference Product  PubMed Publications
 TEC antibody  >2 publications with STAP1 and TEC
 SH3KBP1 antibody  >1 publications with STAP1 and SH3KBP1
 BMX antibody  >1 publications with STAP1 and BMX

Pathways associated with anti-STAP1 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway antibodies  Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway Diagram

Organs/Tissues associated with anti-STAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with STAP1 and Blood
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