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PLEKHC1 (FERMT2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643467

FERMT2 participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PLEKHC1 (FERMT2), Monoclonal Antibody
Full Product Name
PLEKHC1 (FERMT2, KIND2, MIG2, Fermitin Family Homolog 2, Kindlin-2, Mitogen-inducible Gene 2 Protein, Pleckstrin Homology Domain-containing Family C Member 1, DKFZp686G11125, FLJ34213, FLJ44462, UNC112, UNC112B, Mig-2)
Product Gene Name
anti-FERMT2 antibody
Product Synonym Names
Anti -PLEKHC1 (FERMT2, KIND2, MIG2, Fermitin Family Homolog 2, Kindlin-2, Mitogen-inducible Gene 2 Protein, Pleckstrin Homology Domain-containing Family C Member 1, DKFZp686G11125, FLJ34213, FLJ44462, UNC112, UNC112B, Mig-2)
Immunogen Sequence
MALDGIRMPD GCYADGTWEL SVHVTDLNRD VTLRVTGEVH IGGVMLKLVE KLDVKKDWSD HALWWEKKRT WLLKTHWTLD KYGIQADAKL QFTPQHKLLR LQLPNMKYVK VKVNFSDRVF KAVSDICKTF NIRHPEELSL LKKPRDPTKK KKKKLDDQSE DEALELEGPL ITPGSGSIYS SPGLYSKTMT PTYDAHDGSP LSPTSAWFGD SALSEGNPGI LAVSQPITSP EILAKMFKPQ ALLDKAKINQ GWLDSSRSLM EQDVKENEAL LLRFKYYSFF DLNPKYDAIR INQLYEQAKW AILLEEIECT EEEMMMFAAL QYHINKLSIM TSENHLNNSD KEVDEVDAAL SDLEITLEGG KTSTILGDIT SIPELADYIK VFKPKKLTLK GYKQYWCTFK DTSISCYKSK EESSGTPAHQ MNLRGCEVTP DVNISGQKFN IKLLIPVAEG MNEIWLRCDN EKQYAHWMAA CRLASKGKTM ADSSYNLEVQ NILSSLKMQH LNPDPQLIPE QITTDITPEC LVSPRYLKKY KNKQITARIL EAHQNVAQMS LIEAKMRFIQ AWQSLPEFGI THFIARFQGG KKEELIGIAY NRLIRMDAST GDAIKTWRFS NMKQWNVNWE IKMVTVEFAD EVRLSFICTE VDCKVVHEFI GGYIFLSTRA KDQNESLDEE MFYKLTSGWV
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2G11
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PLEKHC1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
77,861 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (53323989..53417856, complement). Location: 14q22.1
OMIM
607746
3D Structure
ModBase 3D Structure for Q96AC1
Immunogen
Full length recombinant corresponding to aa1-681 from human PLEKHC1 (AAH17327) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-FERMT2 antibody

Antibodies; Abs to Pleckstrin Homology Proteins
Applications Tested/Suitable for anti-FERMT2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-FERMT2 antibody
Suitable for use in Immunofluorescence, ELISA and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-FERMT2 antibody

Western Blot analysis of PLEKHC1 expression in transfected 293T cell line by PLEKHC1 monoclonal antibody |Lane 1: PLEKHC1 transfected lysate (77.9kD).|Lane 2: Non-transfected lysate.
Mouse Anti-FERMT2 Monoclonal Antibody – Cat# MBS643467

Immunofluorescence (IF) of anti-FERMT2 antibody

Immunofluorescence of monoclonal antibody to FERMT2 on HeLa cell . [antibody concentration 10ug/ml].
Mouse Anti-FERMT2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS643467

Testing Data of anti-FERMT2 antibody

Detection limit for recombinant GST tagged FERMT2 is 1ng/ml as a capture antibody.
Mouse Anti-FERMT2 Monoclonal Antibody, Testing Data – Cat# MBS643467

Other Notes

Small volumes of anti-FERMT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FERMT2 purchase

MBS643467 is an antibody targeting FERMT2. Also known as PLEKHC1 (FERMT2, KIND2, MIG2, Fermitin Family Homolog 2, Kindlin-2, Mitogen-inducible Gene 2 Protein, Pleckstrin Homology Domain-containing Family C Member 1, DKFZp686G11125, FLJ34213, FLJ44462, UNC112, UNC112B, Mig-2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FERMT2. It may not necessarily be applicable to this product.

NCBI GI #
530402997
NCBI GeneID
10979
NCBI Accession #
XP_005267343.1
UniProt Primary Accession #
Q96AC1
UniProt Secondary Accession #
Q14840; Q86TY7; B5TJY2
UniProt Related Accession #
Q96AC1
GenBank Nucleotide #
XM_005267286.1
NCBI Official Full Name
fermitin family homolog 2 isoform X2
NCBI Official Synonym Full Names
fermitin family member 2
NCBI Official Symbol
FERMT2
NCBI Official Synonym Symbols
MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B
UniProt Protein Name
Fermitin family homolog 2
UniProt Synonym Protein Names
Kindlin-2; Mitogen-inducible gene 2 protein; MIG-2; Pleckstrin homology domain-containing family C member 1
Protein Family
Fermitin family
UniProt Gene Name
FERMT2
UniProt Synonym Gene Names
KIND2; MIG2; PLEKHC1; MIG-2
UniProt Entry Name
FERM2_HUMAN
NCBI Protein Information
fermitin family homolog 2; kindlin 2; kindlin-2; mitogen inducible gene 2 protein; mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain-containing family C member 1; pleckstrin homology domain containing, family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1

UniProt Comments for FERMT2

Kindlin-2: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. Belongs to the kindlin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: nucleoplasm; filamentous actin; I band; extrinsic to internal side of plasma membrane; cell surface; focal adhesion; cytoplasm; stress fiber; cell cortex; cytosol; nucleus

Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding

Biological Process: integrin-mediated signaling pathway; focal adhesion formation; integrin activation; regulation of cell shape; Wnt receptor signaling pathway; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion
Show more

Research Articles on FERMT2

1. Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FERMT2 antibody

 Products by Pathway  Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-extracellular Matrix Interactions Pathway antibodies  Cell-extracellular Matrix Interactions Pathway Diagram

Diseases associated with anti-FERMT2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with FERMT2 and Neoplasms
 Intestinal Neoplasms Antibodies  >2 publications with FERMT2 and Intestinal Neoplasms

Organs/Tissues associated with anti-FERMT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with FERMT2 and Muscle
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