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RYBP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643494

RYBP may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RYBP, Polyclonal Antibody
Full Product Name
RYBP, NT (RYBP, DEDAF, YEAF1, RING1 and YY1-binding protein, Apoptin-associating protein 1, Death effector domain-associated factor, YY1 and E4TF1-associated factor 1)
Product Gene Name
anti-RYBP antibody
Product Synonym Names
Anti -RYBP, NT (RYBP, DEDAF, YEAF1, RING1 and YY1-binding protein, Apoptin-associating protein 1, Death effector domain-associated factor, YY1 and E4TF1-associated factor 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
24,822 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (72423744..72495774, complement). Location: 3p13
OMIM
607535
3D Structure
ModBase 3D Structure for Q8N488
Immunogen
RYBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RYBP.

Product Categories/Family for anti-RYBP antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-RYBP antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-RYBP antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-RYBP antibody

RYBP Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the RYBP antibody detected the RYBP protein (arrow).
Rabbit Anti-RYBP Polyclonal Antibody – Cat# MBS643494

Western Blot (WB) of anti-RYBP antibody

Western blot analysis of RYBP (arrow) using rabbit polyclonal RYBP Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RYBP gene.
Rabbit Anti-RYBP Polyclonal Antibody, Western Blot (WB) – Cat# MBS643494

Other Notes

Small volumes of anti-RYBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RYBP purchase

MBS643494 is an antibody targeting RYBP. Also known as RYBP, NT (RYBP, DEDAF, YEAF1, RING1 and YY1-binding protein, Apoptin-associating protein 1, Death effector domain-associated factor, YY1 and E4TF1-associated factor 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RYBP. It may not necessarily be applicable to this product.

NCBI GI #
112363092
NCBI GeneID
23429
NCBI Accession #
NP_036366.3
UniProt Primary Accession #
Q8N488
UniProt Secondary Accession #
Q9P2W5; Q9UMW4
UniProt Related Accession #
Q8N488
GenBank Nucleotide #
NM_012234.5
NCBI Official Full Name
RING1 and YY1-binding protein
NCBI Official Synonym Full Names
RING1 and YY1 binding protein
NCBI Official Symbol
RYBP
NCBI Official Synonym Symbols
AAP1; DEDAF; YEAF1
UniProt Protein Name
RING1 and YY1-binding protein
UniProt Synonym Protein Names
Apoptin-associating protein 1; APAP-1; Death effector domain-associated factor; DED-associated factor; YY1 and E4TF1-associated factor 1
Protein Family
RING1 and YY1-binding protein
UniProt Gene Name
RYBP
UniProt Synonym Gene Names
DEDAF; YEAF1; APAP-1
UniProt Entry Name
RYBP_HUMAN
NCBI Protein Information
RING1 and YY1-binding protein; APAP-1; DED-associated factor; ring1 interactor RYBP; apoptin-associating protein 1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1; death effector domain-associated factor

UniProt Comments for RYBP

RYBP: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 3p13

Cellular Component: nucleoplasm; cytoplasm; PcG protein complex

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; apoptosis; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on RYBP

1. Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RYBP antibody

 Reference Product  PubMed Publications
 YY1 antibody  >16 publications with RYBP and YY1
 RING1 antibody  >14 publications with RYBP and RING1
 RNF2 antibody  >8 publications with RYBP and RNF2
 FADD antibody  >2 publications with RYBP and FADD
 E2F6 antibody  >2 publications with RYBP and E2F6
 CDC6 antibody  >1 publications with RYBP and CDC6
 E2F2 antibody  >1 publications with RYBP and E2F2
 E2F3 antibody  >1 publications with RYBP and E2F3

Pathways associated with anti-RYBP antibody

 Products by Pathway  Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram

Diseases associated with anti-RYBP antibody

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >2 publications with RYBP and Abnormalities, Multiple
 Liver Neoplasms Antibodies  >1 publications with RYBP and Liver Neoplasms
 Anemia Antibodies  >1 publications with RYBP and Anemia
 Neural Tube Defects Antibodies  >1 publications with RYBP and Neural Tube Defects
 Liver Diseases Antibodies  >1 publications with RYBP and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with RYBP and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >1 publications with RYBP and Hyperplasia
 Necrosis Antibodies  >1 publications with RYBP and Necrosis

Organs/Tissues associated with anti-RYBP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with RYBP and Blood
 Muscle Antibodies  >4 publications with RYBP and Muscle
 Placenta Antibodies  >4 publications with RYBP and Placenta
 Prostate Antibodies  >3 publications with RYBP and Prostate
 Liver Antibodies  >2 publications with RYBP and Liver
 Embryonic Tissue Antibodies  >2 publications with RYBP and Embryonic Tissue
 Brain Antibodies  >2 publications with RYBP and Brain
 Pituitary Gland Antibodies  >1 publications with RYBP and Pituitary Gland
 Thyroid Antibodies  >1 publications with RYBP and Thyroid
 Eye Antibodies  >1 publications with RYBP and Eye
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