PCSK6 Antibody – Goat Polyclonal

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PCSK6: Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: extracellular matrix; extracellular space; cell surface; membrane; Golgi lumen; endoplasmic reticulum

Molecular Function: heparin binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding

Biological Process: nerve growth factor processing; zygotic determination of anterior/posterior axis, embryo; nerve growth factor receptor signaling pathway; glycoprotein metabolic process; regulation of BMP signaling pathway; peptide hormone processing; protein processing; proteolysis; determination of left/right symmetry; nerve growth factor production; secretion by cell