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CC2D1A Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643556

CC2D1A is a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CC2D1A, Polyclonal Antibody
Full Product Name
CC2D1A (AKI1, Coiled-coil and C2 Domain-containing Protein 1A, Akt Kinase-interacting Protein 1, Five Prime Repressor Element Under Dual Repression-binding Protein 1, Putative NF-kappa-B-activating Protein 023N, FLJ20241, FLJ41160)
Product Gene Name
anti-CC2D1A antibody
Product Synonym Names
Anti -CC2D1A (AKI1, Coiled-coil and C2 Domain-containing Protein 1A, Akt Kinase-interacting Protein 1, Five Prime Repressor Element Under Dual Repression-binding Protein 1, Putative NF-kappa-B-activating Protein 023N, FLJ20241, FLJ41160)
Immunogen Sequence
MHKRKGPPGP PGRGAAAARQ LGLLVDLSPD GLMIPEDGAN DEELEAEFLA LVGGQPPALE KLKGKGPLPM EAIEKMASLC MRDPDEDEEE GTDEDDLEAD DDLLAELNEV LGEEQKASET PPPVAQPKPE APHPGLETTL QERLALYQTA IESARQAGDS AKMRRYDRGL KTLENLLASI RKGNAIDEAD IPPPVAIGKG PASTPTYSPA PTQPAPRIAS APEPRVTLEG PSATAPASSP GLAKPQMPPG PCSPGPLAQL QSRQRDYKLA ALHAKQQGDT TAAARHFRVA KSFDAVLEAL SRGEPVDLSC LPPPPDQLPP DPPSPPSQPP TPATAPSTTE VPPPPRTLLE ALEQRMERYQ VAAAQAKSKG DQRKARMHER IVKQYQDAIR AHKAGRAVDV AELPVPPGFP PIQGLEATKP TQQSLVGVLE TAMKLANQDE GPEDEEDEVP KKQNSPVAPT AQPKAPPSRT PQSGSAPTAK APPKATSTRA QQQLAFLEGR KKQLLQAALR AKQKNDVEGA KMHLRQAKGL EPMLEASRNG LPVDITKVPP APVNKDDFAL VQRPGPGLSQ EAARRYGELT KLIRQQHEMC LNHSNQFTQL GNITETTKFE KLAEDCKRSM DILKQAFVRG LPTPTARFEQ RTFSVIKIFP DLSSNDMLLF IVKGINLPTP PGLSPGDLDV FVRFDFPYPN VEEAQKDKTS VIKNTDSPEF KEQFKLCINR SHRGFRRAIQ TKGIKFEVVH KGGLFKTDRV LGTAQLKLDA LEIACEVREI LEVLDGRRPT GGRLEVMVRI REPLTAQQLE TTTERWLVID PVPAAVPTQV AGPKGKAPPV PAPARESGNR SARPLHSLSV LAFDQERLER KILALRQARR PVPPEVAQQY QDIMQRSQWQ RAQLEQGGVG IRREYAAQLE RQLQFYTEAA RRLGNDGSRD AAKEALYRRN LVESELQRLR R
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CC2D1A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
104,062 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (14016956..14041693). Location: 19p13.12
OMIM
608443
3D Structure
ModBase 3D Structure for Q6P1N0
Immunogen
Full length human CC2D1A, aa1-951 (NP_060191.3).

Product Categories/Family for anti-CC2D1A antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-CC2D1A antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CC2D1A antibody
Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
Dilution: Immunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-CC2D1A antibody

CC2D1A polyclonal antibody. Western Blot analysis of CC2D1A expression in human liver.
Mouse Anti-CC2D1A Polyclonal Antibody – Cat# MBS643556

Western Blot (WB) of anti-CC2D1A antibody

CC2D1A polyclonal antibody. Western Blot analysis of CC2D1A expression in Hela NE.
Mouse Anti-CC2D1A Polyclonal Antibody, Western Blot (WB) – Cat# MBS643556

Western Blot (WB) of anti-CC2D1A antibody

Western Blot analysis of CC2D1A expression in transfected 293T cell line by CC2D1A polyclonal antibody. Lane 1: CC2D1A transfected lysate (104.61kD). Lane 2: Non-transfected lysate.
Mouse Anti-CC2D1A Polyclonal Antibody, Western Blot (WB) – Cat# MBS643556

Immunohistochemistry (IHC) of anti-CC2D1A antibody

Immunoperoxidase of purified antibody to CC2D1A on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3ug/ml].
Mouse Anti-CC2D1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS643556

Immunofluorescence (IF) of anti-CC2D1A antibody

Immunofluorescence of purified antibody to CC2D1A on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-CC2D1A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS643556

Other Notes

Small volumes of anti-CC2D1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CC2D1A purchase

MBS643556 is an antibody targeting CC2D1A. Also known as CC2D1A (AKI1, Coiled-coil and C2 Domain-containing Protein 1A, Akt Kinase-interacting Protein 1, Five Prime Repressor Element Under Dual Repression-binding Protein 1, Putative NF-kappa-B-activating Protein 023N, FLJ20241, FLJ41160). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CC2D1A. It may not necessarily be applicable to this product.

NCBI GI #
96974985
NCBI GeneID
54862
NCBI Accession #
NP_060191.3
UniProt Primary Accession #
Q6P1N0
UniProt Secondary Accession #
Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1
UniProt Related Accession #
Q6P1N0
GenBank Nucleotide #
NM_017721.4
NCBI Official Full Name
coiled-coil and C2 domain-containing protein 1A
NCBI Official Synonym Full Names
coiled-coil and C2 domain containing 1A
NCBI Official Symbol
CC2D1A
NCBI Official Synonym Symbols
MRT3; FREUD-1; Freud-1/Aki1
UniProt Protein Name
Coiled-coil and C2 domain-containing protein 1A
UniProt Synonym Protein Names
Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N
Protein Family
Coiled-coil and C2 domain-containing protein
UniProt Gene Name
CC2D1A
UniProt Synonym Gene Names
AKI1; FRE under dual repression-binding protein 1; Freud-1
UniProt Entry Name
C2D1A_HUMAN
NCBI Protein Information
coiled-coil and C2 domain-containing protein 1A; Akt kinase-interacting protein 1; putative NFkB activating protein; FRE under dual repression-binding protein 1; putative NF-kappa-B-activating protein 023N; mental retardation, nonsyndromic, autosomal recessive, 3; five repressor element under dual repression-binding protein 1; five prime repressor element under dual repression-binding protein 1

NCBI Summary for CC2D1A

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.[provided by RefSeq, Oct 2009]
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UniProt Comments for CC2D1A

CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus

Molecular Function: signal transducer activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Disease: Mental Retardation, Autosomal Recessive 3
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Research Articles on CC2D1A

1. Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CC2D1A antibody

 Reference Product  PubMed Publications
 PRSS12 antibody  >3 publications with CC2D1A and PRSS12
 CHMP4A antibody  >1 publications with CC2D1A and CHMP4A
 DRD2 antibody  >1 publications with CC2D1A and DRD2
 HTR1A antibody  >1 publications with CC2D1A and HTR1A

Pathways associated with anti-CC2D1A antibody

 Products by Pathway  Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with anti-CC2D1A antibody

 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >13 publications with CC2D1A and Neurobehavioral Manifestations
 Mental Retardation, Autosomal Recessive 3 Antibodies  >5 publications with CC2D1A and Mental Retardation, Autosomal Recessive 3
 Brain Diseases Antibodies  >2 publications with CC2D1A and Brain Diseases
 Congenital Abnormalities Antibodies  >2 publications with CC2D1A and Congenital Abnormalities
 Learning Disorders Antibodies  >1 publications with CC2D1A and Learning Disorders

Organs/Tissues associated with anti-CC2D1A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with CC2D1A and Brain
 Blood Antibodies  >2 publications with CC2D1A and Blood
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