NKX6-1 Antibody – Mouse Monoclonal

NKX6-1: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q21.33

Cellular Component: nucleoplasm

Molecular Function: chromatin binding

Biological Process: transcription from RNA polymerase II promoter; response to nicotine; response to drug; smoothened signaling pathway; positive regulation of insulin secretion; positive regulation of glial cell differentiation; regulation of axon extension; negative regulation of transcription from RNA polymerase II promoter; endocrine pancreas development; negative regulation of glial cell differentiation; cell proliferation; organ morphogenesis; detection of glucose; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; pancreas development; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; positive regulation of transcription factor activity; positive regulation of neuron differentiation