Rabbit Anti-NLRP10 Polyclonal Antibody – Cat# MBS643587

NLRP10 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP10 antibody detected the NLRP10 protein (arrow).

NLRP10 Antibody – Rabbit Polyclonal

Name: NLRP10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS643587
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643587

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NLRP10, Polyclonal Antibody

Full Product Name

NLRP10, CT (NLRP10, NALP10, NOD8, PYNOD, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8)

Product Gene Name

anti-NLRP10 antibody

Product Synonym Names

Anti -NLRP10, CT (NLRP10, NALP10, NOD8, PYNOD, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

75,032 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (7981156..7985059, complement). Location: 11p15.4

OMIM

609662

3D Structure

ModBase 3D Structure for Q86W26

Immunogen

NLRP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human NLRP10.

Product Categories/Family for anti-NLRP10 antibody

Antibodies; Abs to Binding Proteins

Applications Tested/Suitable for anti-NLRP10 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-NLRP10 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-NLRP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRP10 purchase

MBS643587 is an antibody targeting NLRP10. Also known as NLRP10, CT (NLRP10, NALP10, NOD8, PYNOD, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP10. It may not necessarily be applicable to this product.

NCBI GI #

28827807

NCBI GeneID

338322

NCBI Accession #

NP_789791.1

UniProt Primary Accession #

Q86W26

UniProt Secondary Accession #

Q2M3C4; Q6JGT0

UniProt Related Accession #

Q86W26

GenBank Nucleotide #

NM_176821.3

NCBI Official Full Name

NACHT, LRR and PYD domains-containing protein 10

NCBI Official Synonym Full Names

NLR family, pyrin domain containing 10

NCBI Official Symbol

NLRP10

NCBI Official Synonym Symbols

NOD8; PAN5; PYNOD; NALP10; CLR11.1

UniProt Protein Name

NACHT, LRR and PYD domains-containing protein 10

UniProt Synonym Protein Names

Nucleotide-binding oligomerization domain protein 8

Protein Family

NACHT, LRR and PYD domains-containing protein

UniProt Gene Name

NLRP10

UniProt Synonym Gene Names

NALP10; NOD8; PYNOD

UniProt Entry Name

NAL10_HUMAN

NCBI Protein Information

NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10

NCBI Summary for NLRP10

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

UniProt Comments for NLRP10

NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: extrinsic to plasma membrane; cytoplasm

Molecular Function: ATP binding

Biological Process: positive regulation of T-helper 1 type immune response; innate immune response; defense response to Gram-negative bacterium; defense response to fungus

Research Articles on NLRP10

1. These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLRP10 antibody

Reference Product	PubMed Publications
CASP1 antibody	>5 publications with NLRP10 and CASP1
BECN1 antibody	>1 publications with NLRP10 and BECN1

Pathways associated with anti-NLRP10 antibody

Products by Pathway	Pathway Diagram
NOD Pathway antibodies	NOD Pathway Diagram

Diseases associated with anti-NLRP10 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>2 publications with NLRP10 and Necrosis