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IFT57 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643595

IFT57 is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit… More details

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Product Overview

Online Datasheet in PDF
Product Name
IFT57, Polyclonal Antibody
Full Product Name
IFT57 (DERP8, ESRRBL1, HIPPI, Intraflagellar Transport Protein 57 Homolog, Dermal Papilla-derived Protein 8, Estrogen-related Receptor beta-like Protein 1, HIP1-interacting Protein, MHS4R2, FLJ10147)
Product Gene Name
anti-IFT57 antibody
Product Synonym Names
Anti -IFT57 (DERP8, ESRRBL1, HIPPI, Intraflagellar Transport Protein 57 Homolog, Dermal Papilla-derived Protein 8, Estrogen-related Receptor beta-like Protein 1, HIP1-interacting Protein, MHS4R2, FLJ10147)
Immunogen Sequence
MTAALAVVTT SGLEDGVPRS RGEGTGEVVL ERGPGAAYHM FVVMEDLVEK LKLLRYEEEF LRKSNLKAPS RHYFALPTNP GEQFYMFCTL AAWLINKAGR PFEQPQEYDD PNATISNILS ELRSFGRTAD FPPSKLKSGY GEHVCYVLDC FAEEALKYIG FTWKRPIYPV EELEEESVAE DDAELTLNKV DEEFVEEETD NEENFIDLNV LKAQTYHLDM NETAKQEDIL ESTTDAAEWS LEVERVLPQL KVTIRTDNKD WRIHVDQMHQ HRSGIESALK ETKGFLDKLH NEITRTLEKI SSREKYINNQ LENLVQEYRA AQAQLSEAKE RYQQGNGGVT ERTRLLSEVM EELEKVKQEM EEKGSSMTDG APLVKIKQSL TKLKQETVEM DIRIGIVEHT LLQSKLKEKS NMTRNMHATV IPEPATGFY
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human IFT57. Species Crossreactivity: Mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
49,108 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (107879659..107941417, complement). Location: 3q13.13
OMIM
606621
3D Structure
ModBase 3D Structure for Q9NWB7
Immunogen
Full length human IFT57, aa1-429 (NP_060480.1).

Product Categories/Family for anti-IFT57 antibody

Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-IFT57 antibody
Western Blot (WB)
Application Notes for anti-IFT57 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-IFT57 antibody

IFT57 rabbit polyclonal antibody. Western Blot analysis of IFT57 expression in mouse liver.
Rabbit Anti-IFT57 Polyclonal Antibody – Cat# MBS643595

Western Blot (WB) of anti-IFT57 antibody

Western Blot analysis of IFT57 expression in transfected 293T cell line by IFT57 polyclonal antibody. Lane 1: IFT57 transfected lysate (49.1kD). Lane 2: Non-transfected lysate.
Rabbit Anti-IFT57 Polyclonal Antibody, Western Blot (WB) – Cat# MBS643595

Other Notes

Small volumes of anti-IFT57 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFT57 purchase

MBS643595 is an antibody targeting IFT57. Also known as IFT57 (DERP8, ESRRBL1, HIPPI, Intraflagellar Transport Protein 57 Homolog, Dermal Papilla-derived Protein 8, Estrogen-related Receptor beta-like Protein 1, HIP1-interacting Protein, MHS4R2, FLJ10147). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFT57. It may not necessarily be applicable to this product.

NCBI GI #
34783880
NCBI GeneID
55081
NCBI Accession #
AAH09690.2
UniProt Primary Accession #
Q9NWB7
UniProt Secondary Accession #
Q96DA9
UniProt Related Accession #
Q9NWB7
NCBI Official Full Name
IFT57 protein, partial
NCBI Official Synonym Full Names
intraflagellar transport 57 homolog (Chlamydomonas)
NCBI Official Symbol
IFT57
NCBI Official Synonym Symbols
HIPPI; MHS4R2; ESRRBL1
UniProt Protein Name
Intraflagellar transport protein 57 homolog
UniProt Synonym Protein Names
Dermal papilla-derived protein 8; Estrogen-related receptor beta-like protein 1; HIP1-interacting protein; MHS4R2
Protein Family
Intraflagellar transport protein
UniProt Gene Name
IFT57
UniProt Synonym Gene Names
DERP8; ESRRBL1; HIPPI
UniProt Entry Name
IFT57_HUMAN
NCBI Protein Information
intraflagellar transport protein 57 homolog; HIP1 protein interactor; HIP1-interacting protein; dermal papilla-derived protein 8; estrogen-related receptor beta like 1; estrogen-related receptor beta-like protein 1; huntingtin interacting protein-1 interacting protein

UniProt Comments for IFT57

IFT57: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family.

Chromosomal Location of Human Ortholog: 3q13.13

Cellular Component: Golgi apparatus; centrosome; photoreceptor connecting cilium; cilium

Molecular Function: protein binding; DNA binding

Biological Process: regulation of apoptosis; caspase activation; smoothened signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; organelle organization and biogenesis; neural tube closure; intraflagellar transport; cilium biogenesis; heart looping; negative regulation of epithelial cell proliferation
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Research Articles on IFT57

1. HIPPI-P53 interaction was necessary for HIPPI mediated up-regulation of Caspase1 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFT57 antibody

 Reference Product  PubMed Publications
 HIP1 antibody  >13 publications with IFT57 and HIP1
 CASP8 antibody  >6 publications with IFT57 and CASP8
 HTT antibody  >5 publications with IFT57 and HTT
 IFT52 antibody  >4 publications with IFT57 and IFT52
 IFT20 antibody  >4 publications with IFT57 and IFT20
 IFT172 antibody  >3 publications with IFT57 and IFT172
 IFT80 antibody  >2 publications with IFT57 and IFT80
 BLOC1S2 antibody  >1 publications with IFT57 and BLOC1S2
 RYBP antibody  >1 publications with IFT57 and RYBP

Pathways associated with anti-IFT57 antibody

 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram

Diseases associated with anti-IFT57 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with IFT57 and Nervous System Diseases
 Brain Diseases Antibodies  >6 publications with IFT57 and Brain Diseases
 Neural Tube Defects Antibodies  >1 publications with IFT57 and Neural Tube Defects
 Cardiovascular Diseases Antibodies  >1 publications with IFT57 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >1 publications with IFT57 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with IFT57 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with IFT57 and Necrosis

Organs/Tissues associated with anti-IFT57 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >6 publications with IFT57 and Eye
 Brain Antibodies  >4 publications with IFT57 and Brain
 Kidney Antibodies  >2 publications with IFT57 and Kidney
 Blood Antibodies  >2 publications with IFT57 and Blood
 Muscle Antibodies  >1 publications with IFT57 and Muscle
 Testis Antibodies  >1 publications with IFT57 and Testis
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