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SAP18 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643620

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which… More details

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Product Overview

Online Datasheet in PDF
Product Name
SAP18, Polyclonal Antibody
Full Product Name
SAP18 (Histone Deacetylase Complex Subunit SAP18, 18kD Sin3-associated Polypeptide, 2HOR0202, Cell Growth-inhibiting Gene 38 Protein, Sin3-associated Polypeptide p18)
Product Gene Name
anti-SAP18 antibody
Product Synonym Names
Anti -SAP18 (Histone Deacetylase Complex Subunit SAP18, 18kD Sin3-associated Polypeptide, 2HOR0202, Cell Growth-inhibiting Gene 38 Protein, Sin3-associated Polypeptide p18)
Immunogen Sequence
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SAP18.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
17,561 Da
Chromosome Location
Chromosome: 13; NC_000013.10 (21714653..21723224). Location: 13q12.11
OMIM
602949
3D Structure
ModBase 3D Structure for O00422
Immunogen
Full-length human SAP18, aa1-153 (NP_005861.1).

Product Categories/Family for anti-SAP18 antibody

Antibodies; Abs to Histones
Applications Tested/Suitable for anti-SAP18 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SAP18 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-SAP18 antibody

Western Blot analysis of SAP18 expression in transfected 293T cell line by SAP18 polyclonal antibody. Lane 1: SAP18 transfected lysate (16.83KD). Lane 2: Non-transfected lysate.
Mouse Anti-SAP18 Polyclonal Antibody – Cat# MBS643620

Immunofluorescence (IF) of anti-SAP18 antibody

Immunofluorescence of purified antibody to SAP18 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-SAP18 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS643620

Other Notes

Small volumes of anti-SAP18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SAP18 purchase

MBS643620 is an antibody targeting SAP18. Also known as SAP18 (Histone Deacetylase Complex Subunit SAP18, 18kD Sin3-associated Polypeptide, 2HOR0202, Cell Growth-inhibiting Gene 38 Protein, Sin3-associated Polypeptide p18). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SAP18. It may not necessarily be applicable to this product.

NCBI GI #
48146187
NCBI GeneID
10284
NCBI Accession #
CAG33316.1
UniProt Primary Accession #
O00422
UniProt Secondary Accession #
Q2TTR4; Q6IAW9; Q8N606; Q9UF14; B2R494
UniProt Related Accession #
O00422
NCBI Official Full Name
SAP18
NCBI Official Synonym Full Names
Sin3A-associated protein, 18kDa
NCBI Official Symbol
SAP18
NCBI Official Synonym Symbols
SAP18P; 2HOR0202
UniProt Protein Name
Histone deacetylase complex subunit SAP18
UniProt Synonym Protein Names
18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18
Protein Family
Zinc finger A20 domain-containing stress-associated protein
UniProt Gene Name
SAP18
UniProt Entry Name
SAP18_HUMAN
NCBI Protein Information
histone deacetylase complex subunit SAP18; sin3-associated polypeptide p18; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; cell growth-inhibiting protein 38; 18 kDa Sin3-associated polypeptide; sin3-associated polypeptide, 18 kDa; cell growth-inhibiting gene 38 protein; histone deacetlyase complex subunit SAP18

UniProt Comments for SAP18

SAP18: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family.

Chromosomal Location of Human Ortholog: 13q12.11

Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nuclear speck

Molecular Function: protein binding; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of apoptosis; negative regulation of gene expression, epigenetic; RNA splicing; gene expression; mRNA processing; regulation of gene expression, epigenetic; regulation of alternative nuclear mRNA splicing, via spliceosome
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Research Articles on SAP18

1. A novel function of SAP18 in splicing regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SAP18 antibody

 Reference Product  PubMed Publications
 RNPS1 antibody  >6 publications with SAP18 and RNPS1
 ACIN1 antibody  >5 publications with SAP18 and ACIN1
 HDAC1 antibody  >5 publications with SAP18 and HDAC1
 SIN3A antibody  >5 publications with SAP18 and SIN3A
 SAP30 antibody  >4 publications with SAP18 and SAP30
 SUFU antibody  >2 publications with SAP18 and SUFU
 RBBP7 antibody  >1 publications with SAP18 and RBBP7
 RBBP4 antibody  >1 publications with SAP18 and RBBP4

Pathways associated with anti-SAP18 antibody

 Products by Pathway  Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram

Diseases associated with anti-SAP18 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with SAP18 and Neoplasms

Organs/Tissues associated with anti-SAP18 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with SAP18 and Bone
 Muscle Antibodies  >2 publications with SAP18 and Muscle
 Ovary Antibodies  >2 publications with SAP18 and Ovary
 Embryonic Tissue Antibodies  >2 publications with SAP18 and Embryonic Tissue
 Salivary Gland Antibodies  >1 publications with SAP18 and Salivary Gland
 Mouth Antibodies  >1 publications with SAP18 and Mouth
 Testis Antibodies  >1 publications with SAP18 and Testis
 Brain Antibodies  >1 publications with SAP18 and Brain
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