Rabbit Anti-CDA Polyclonal Antibody – Cat# MBS643635

Human Spleen (formalin-fixed, paraffin-embedded) stained with CDA antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.

Cytidine Deaminase (CDA) Antibody – Rabbit Polyclonal

Name: CDA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS643635
Price: 935 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643635

Cytidine deaminase (CDA), an enzyme involved in pyrimidine salvaging, forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. CDA is one of several deaminases… More details

$935 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cytidine Deaminase (CDA), Polyclonal Antibody

Full Product Name

Cytidine Deaminase, NT (CDA, Cytidine Aminohydrolase, CDD)

Product Gene Name

anti-CDA antibody

Product Synonym Names

Anti -Cytidine Deaminase, NT (CDA, Cytidine Aminohydrolase, CDD)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.01% sodium azide, 50% glycerol.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human CDA.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

16,185 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (20915444..20945401). Location: 1p36.2-p35

OMIM

123920

3D Structure

ModBase 3D Structure for P32320

Immunogen

Synthetic peptide corresponding to human CDA at N-terminal (KLH).

Product Categories/Family for anti-CDA antibody

Antibodies; Abs to Enzymes

Applications Tested/Suitable for anti-CDA antibody

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-CDA antibody

Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1ug/ml
Western Blot: 1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Other Notes

Small volumes of anti-CDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDA purchase

MBS643635 is an antibody targeting CDA. Also known as Cytidine Deaminase, NT (CDA, Cytidine Aminohydrolase, CDD). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDA. It may not necessarily be applicable to this product.

NCBI GI #

11386157

NCBI GeneID

978

NCBI Accession #

NP_001776.1

UniProt Primary Accession #

P32320

UniProt Related Accession #

P32320

GenBank Nucleotide #

NM_001785.2

NCBI Official Full Name

cytidine deaminase

NCBI Official Synonym Full Names

cytidine deaminase

NCBI Official Symbol

CDA

NCBI Official Synonym Symbols

CDD

UniProt Protein Name

Cytidine deaminase

UniProt Synonym Protein Names

Cytidine aminohydrolase

Protein Family

Calcium-transporting ATPase

UniProt Gene Name

CDA

UniProt Synonym Gene Names

CDD

UniProt Entry Name

CDD_HUMAN

NCBI Protein Information

cytidine deaminase; cytidine aminohydrolase; small cytidine deaminase; cytosine nucleoside deaminase

NCBI Summary for CDA

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

UniProt Comments for CDA

CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: EC 3.5.4.5; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase

Chromosomal Location of Human Ortholog: 1p36.2-p35

Cellular Component: extracellular region; cytosol

Molecular Function: protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity

Biological Process: cell surface receptor linked signal transduction; cytosine metabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; cytidine deamination; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization

Research Articles on CDA

1. Variation in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDA antibody

Reference Product	PubMed Publications
DCK antibody	>71 publications with CDA and DCK
ADA antibody	>25 publications with CDA and ADA
TK1 antibody	>3 publications with CDA and TK1
PNP antibody	>2 publications with CDA and PNP

Pathways associated with anti-CDA antibody

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Salvage Reactions Pathway antibodies	Pyrimidine Salvage Reactions Pathway Diagram
Pyrimidine Deoxyribonucleosides Degradation Pathway antibodies	Pyrimidine Deoxyribonucleosides Degradation Pathway Diagram

Diseases associated with anti-CDA antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>595 publications with CDA and Neoplasms
Anemia Antibodies	>251 publications with CDA and Anemia
Anemia, Hemolytic Antibodies	>201 publications with CDA and Anemia, Hemolytic
Bone Marrow Diseases Antibodies	>85 publications with CDA and Bone Marrow Diseases
Neutropenia Antibodies	>80 publications with CDA and Neutropenia
Nervous System Diseases Antibodies	>80 publications with CDA and Nervous System Diseases
Thrombocytopenia Antibodies	>70 publications with CDA and Thrombocytopenia
Lung Diseases Antibodies	>61 publications with CDA and Lung Diseases
Carcinoma Antibodies	>51 publications with CDA and Carcinoma
Neoplasms, Experimental Antibodies	>38 publications with CDA and Neoplasms, Experimental

Organs/Tissues associated with anti-CDA antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>502 publications with CDA and Blood
Bone Antibodies	>298 publications with CDA and Bone
Bone Marrow Antibodies	>230 publications with CDA and Bone Marrow
Brain Antibodies	>70 publications with CDA and Brain
Liver Antibodies	>64 publications with CDA and Liver
Skin Antibodies	>55 publications with CDA and Skin
Kidney Antibodies	>53 publications with CDA and Kidney
Lung Antibodies	>40 publications with CDA and Lung
Spleen Antibodies	>30 publications with CDA and Spleen
Eye Antibodies	>17 publications with CDA and Eye