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EIF3S5 (EIF3F) Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643686

EIF3F is part of the EIF3 complex, which is composed of at least 12 subunits. It binds the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. It can bind the COP9 signalosome and the 26S proteasome, possibly having regulatory functions in both… More details

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Product Overview

Online Datasheet in PDF
Product Name
EIF3S5 (EIF3F), Polyclonal Antibody
Full Product Name
EIF3S5 (Eukaryotic Translation Initiation Factor 3 Subunit F, eIF3f, Eukaryotic Translation Initiation Factor 3 Subunit 5, eIF-3-epsilon, eIF3 p47, EIF3F)
Product Gene Name
anti-EIF3F antibody
Product Synonym Names
Anti -EIF3S5 (Eukaryotic Translation Initiation Factor 3 Subunit F, eIF3f, Eukaryotic Translation Initiation Factor 3 Subunit 5, eIF-3-epsilon, eIF3 p47, EIF3F)
Immunogen Sequence
MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human EIF3S5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,564 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (8008867..8017718). Location: 11p15.4
OMIM
603914
3D Structure
ModBase 3D Structure for O00303
Immunogen
Full length human EIF3S5, aa1-357 (AAH00490).

Product Categories/Family for anti-EIF3F antibody

Antibodies; Abs to Translation Initiation Factors
Applications Tested/Suitable for anti-EIF3F antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-EIF3F antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Immunofluorescence (IF) of anti-EIF3F antibody

Immunofluorescence of purified antibody to EIF3S5 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-EIF3F Polyclonal Antibody – Cat# MBS643686

Western Blot (WB) of anti-EIF3F antibody

Western Blot analysis of EIF3F expression in transfected 293T cell line by EIF3F polyclonal antibody. Lane 1: EIF3S5 transfected lysate (39.27kD). Lane 2: Non-transfected lysate.
Mouse Anti-EIF3F Polyclonal Antibody, Western Blot (WB) – Cat# MBS643686

Western Blot (WB) of anti-EIF3F antibody

EIF3S5 polyclonal antibody. Western Blot analysis of EIF3S5 expression in human spleen.
Mouse Anti-EIF3F Polyclonal Antibody, Western Blot (WB) – Cat# MBS643686

Other Notes

Small volumes of anti-EIF3F antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIF3F purchase

MBS643686 is an antibody targeting EIF3F. Also known as EIF3S5 (Eukaryotic Translation Initiation Factor 3 Subunit F, eIF3f, Eukaryotic Translation Initiation Factor 3 Subunit 5, eIF-3-epsilon, eIF3 p47, EIF3F). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF3F. It may not necessarily be applicable to this product.

NCBI GI #
4503519
NCBI GeneID
8665
NCBI Accession #
NP_003745.1
UniProt Primary Accession #
O00303
UniProt Secondary Accession #
Q6IB45; Q8N978; A8K0S2
UniProt Related Accession #
O00303
GenBank Nucleotide #
NM_003754.2
NCBI Official Full Name
eukaryotic translation initiation factor 3 subunit F
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 3, subunit F
NCBI Official Symbol
EIF3F
NCBI Official Synonym Symbols
EIF3S5; eIF3-p47
UniProt Protein Name
Eukaryotic translation initiation factor 3 subunit F
UniProt Synonym Protein Names
Deubiquitinating enzyme eIF3f; eIF-3-epsilon; eIF3 p47
UniProt Gene Name
EIF3F
UniProt Synonym Gene Names
eIF3f
UniProt Entry Name
EIF3F_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 3 subunit F; eIF3-epsilon; eIF-3-epsilon; deubiquitinating enzyme eIF3f; eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa

UniProt Comments for EIF3F

eIF3-epsilon: eukaryotic translation initiation factor 3, subunit 5 epsilon. Binds to the 40s ribosome and promotes the binding of methionyl-tRNAi and mRNA. Associates with the complex p170-eIF3. eIF-3 is composed of at least 12 different subunits.

Protein type: Translation; EC 3.4.19.12; Translation initiation

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: eukaryotic translation initiation factor 3 complex; membrane; cytosol

Molecular Function: protein binding; translation initiation factor binding; translation initiation factor activity; ubiquitin-specific protease activity

Biological Process: cellular protein metabolic process; protein deubiquitination; translation; translational initiation; gene expression; proteolysis; formation of translation preinitiation complex; regulation of translational initiation
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Research Articles on EIF3F

1. findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EIF3F antibody

 Reference Product  PubMed Publications
 EIF3E antibody  >21 publications with EIF3F and EIF3E
 EIF3H antibody  >7 publications with EIF3F and EIF3H
 EIF3I antibody  >4 publications with EIF3F and EIF3I
 EIF3B antibody  >3 publications with EIF3F and EIF3B
 EIF3A antibody  >3 publications with EIF3F and EIF3A
 EIF3G antibody  >2 publications with EIF3F and EIF3G
 EIF3C antibody  >2 publications with EIF3F and EIF3C
 EIF3M antibody  >2 publications with EIF3F and EIF3M
 EIF3L antibody  >1 publications with EIF3F and EIF3L

Pathways associated with anti-EIF3F antibody

 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Formation Of A Pool Of Free 40S Subunits Pathway antibodies  Formation Of A Pool Of Free 40S Subunits Pathway Diagram
 Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway antibodies  Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway antibodies  L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram

Diseases associated with anti-EIF3F antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with EIF3F and Neoplasms
 Adenocarcinoma Antibodies  >2 publications with EIF3F and Adenocarcinoma
 Hypertrophy Antibodies  >2 publications with EIF3F and Hypertrophy
 Weight Loss Antibodies  >1 publications with EIF3F and Weight Loss
 Prostatic Diseases Antibodies  >1 publications with EIF3F and Prostatic Diseases
 Necrosis Antibodies  >1 publications with EIF3F and Necrosis
 Inflammation Antibodies  >1 publications with EIF3F and Inflammation

Organs/Tissues associated with anti-EIF3F antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with EIF3F and Muscle
 Ovary Antibodies  >2 publications with EIF3F and Ovary
 Blood Antibodies  >1 publications with EIF3F and Blood
 Embryonic Tissue Antibodies  >1 publications with EIF3F and Embryonic Tissue
 Lung Antibodies  >1 publications with EIF3F and Lung
 Liver Antibodies  >1 publications with EIF3F and Liver
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