UGT1A9 Antibody – Mouse Monoclonal

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]

UGT1A9: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - pentose and glucuronate interconversions; Endoplasmic reticulum; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - androgen and estrogen; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: enzyme inhibitor activity; protein homodimerization activity; retinoic acid binding; enzyme binding; protein heterodimerization activity; glucuronosyltransferase activity

Biological Process: negative regulation of transferase activity; flavonoid biosynthetic process; metabolic process; xenobiotic metabolic process; flavone metabolic process; retinoic acid metabolic process; cellular lipid metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; cellular response to hormone stimulus