Sheep Anti-PGPEP1 Polyclonal Antibody – Cat# MBS643714

Detection of Human and Mouse PGPEP-1 by Western Blot. Western blot shows lysates of LNCaP human prostate cancer cell line, JAR human choriocarcinoma cell line, NTera-2 human testicular embryonic carcinoma cell line, Neuro-2A mouse neuroblastoma cell line, and human brain (cortex) tissue. PVDF membrane was probed with 1ug/ml of Sheep Human PGPEP-1 Antigen Affinity-purified Polyclonal Antibody followed by HRP-conjugated Sheep IgG Secondary Antibody. A specific band was detected for PGPEP-1 at approximately 23kD. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PGPEP1 Antibody – Sheep Polyclonal

Name: PGPEP1 Antibody; Polyclonal; Sheep; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS643714
Price: 1105 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643714

Pyroglutamyl peptidase-1 is an omega peptidase which removes pyroglutamyl residues from the amino termini of peptides and proteins. It is a cytosolic cysteine peptidase that is expressed in most cell types. The enzyme requires a thiol-reducing agent for… More details

$1105 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PGPEP1, Polyclonal Antibody

Full Product Name

PGPEP1 (Pyroglutamyl-peptidase 1, 5-oxoprolyl-peptidase, Pyroglutamyl Aminopeptidase I, PAP-I, Pyroglutamyl-peptidase I, PGP-I, Pyrrolidone-carboxylate Peptidase, PGPI)

Product Gene Name

anti-PGPEP1 antibody

Product Synonym Names

Anti -PGPEP1 (Pyroglutamyl-peptidase 1, 5-oxoprolyl-peptidase, Pyroglutamyl Aminopeptidase I, PAP-I, Pyroglutamyl-peptidase I, PGP-I, Pyrrolidone-carboxylate Peptidase, PGPI)

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human PGPEP-1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

23,138 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (18451397..18480763). Location: 19p13.11

OMIM

610694

3D Structure

ModBase 3D Structure for Q9NXJ5

Immunogen

Recombinant corresponding to aa1-209 from human PGPEP-1 expressed in E.coli.

Product Categories/Family for anti-PGPEP1 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)

Applications Tested/Suitable for anti-PGPEP1 antibody

Western Blot (WB)

Application Notes for anti-PGPEP1 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/ml

Other Notes

Small volumes of anti-PGPEP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGPEP1 purchase

MBS643714 is an antibody targeting PGPEP1. Also known as PGPEP1 (Pyroglutamyl-peptidase 1, 5-oxoprolyl-peptidase, Pyroglutamyl Aminopeptidase I, PAP-I, Pyroglutamyl-peptidase I, PGP-I, Pyrrolidone-carboxylate Peptidase, PGPI). Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for PGPEP1. It may not necessarily be applicable to this product.

NCBI GI #

116283745

NCBI GeneID

54858

NCBI Accession #

AAH28063.1

UniProt Primary Accession #

Q9NXJ5

UniProt Secondary Accession #

A8K1Q3

UniProt Related Accession #

Q9NXJ5

NCBI Official Full Name

PGPEP1 protein

NCBI Official Synonym Full Names

pyroglutamyl-peptidase I

NCBI Official Symbol

PGPEP1

NCBI Official Synonym Symbols

PGP; Pcp; PGPI; PGP-I

UniProt Protein Name

Pyroglutamyl-peptidase 1

UniProt Synonym Protein Names

5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase

Protein Family

Pyroglutamyl-peptidase

UniProt Gene Name

PGPEP1

UniProt Synonym Gene Names

PGPI; PAP-I; PGP-I

UniProt Entry Name

PGPI_HUMAN

NCBI Protein Information

pyroglutamyl-peptidase 1; PAP-I; 5-oxoprolyl-peptidase; pyroglutamyl aminopeptidase I; pyrrolidone-carboxylate peptidase

NCBI Summary for PGPEP1

Pyroglutamyl peptidase I (EC 3.4.19.3) catalyzes the hydrolysis of N-terminal pyroglutamyl residues from oligopeptides and proteins.[supplied by OMIM, Mar 2008]

UniProt Comments for PGPEP1

PGPEP1: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Belongs to the peptidase C15 family.

Protein type: Protease; EC 3.4.19.3

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytosol

Molecular Function: pyroglutamyl-peptidase activity; cysteine-type peptidase activity

Biological Process: proteolysis

Research Articles on PGPEP1

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PGPEP1 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>1 publications with PGPEP1 and Congenital Abnormalities
Disease Models, Animal Antibodies	>1 publications with PGPEP1 and Disease Models, Animal

Organs/Tissues associated with anti-PGPEP1 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>1 publications with PGPEP1 and Intestine
Brain Antibodies	>1 publications with PGPEP1 and Brain