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MGAT3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643754

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. MGAT3 (N-acetylglucosaminyltransferase III) transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MGAT3, Monoclonal Antibody
Full Product Name
MGAT3 (Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, GGNT3, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, N-acetylglucosaminyltransferase III, GlcNAc-T III, GNT-III, FLJ43371, MGC141943, MGC142278)
Product Gene Name
anti-MGAT3 antibody
Product Synonym Names
Anti -MGAT3 (Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, GGNT3, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, N-acetylglucosaminyltransferase III, GlcNAc-T III, GNT-III, FLJ43371, MGC141943, MGC142278)
Immunogen Sequence
LVSAQNGDFP RWGDYEDKRD LNYIRGLIRT GGWFDGTQQE YPPADPSEHM YAPKYLLKNY DRFHYLLDNP YQEPRSTAAG GWRHRGPEGR PPARGKLDEA EV
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2G4
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human MGAT3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
61,313 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (39843235..39888199). Location: 22q13.1
OMIM
604621
3D Structure
ModBase 3D Structure for Q09327
Immunogen
Partial recombinant corresponding to aa430-532 from human MGAT3 (NP_002400) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-MGAT3 antibody

Antibodies; Abs to Carbohydrates; Glycoproteins
Applications Tested/Suitable for anti-MGAT3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-MGAT3 antibody
Suitable for use in ELISA, Western Blot and Immunoprecipitation.

Western Blot (WB) of anti-MGAT3 antibody

Western Blot detection against Immunogen (36.96kD).
Mouse Anti-MGAT3 Monoclonal Antibody – Cat# MBS643754

Western Blot (WB) of anti-MGAT3 antibody

Western Blot analysis of MGAT3 expression in transfected 293T cell line by MGAT3 monoclonal antibody.|Lane 1: MGAT3 transfected lysate (Predicted MW: 61.3kD).|Lane 2: Non-transfected lysate.
Mouse Anti-MGAT3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS643754

Immunoprecipitation (IP) of anti-MGAT3 antibody

Immunoprecipitation of MGAT3 transfected lysate using anti-MGAT3 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with MGAT3 rabbit polyclonal antibody.
Mouse Anti-MGAT3 Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS643754

Other Notes

Small volumes of anti-MGAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MGAT3 purchase

MBS643754 is an antibody targeting MGAT3. Also known as MGAT3 (Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, GGNT3, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, N-acetylglucosaminyltransferase III, GlcNAc-T III, GNT-III, FLJ43371, MGC141943, MGC142278). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MGAT3. It may not necessarily be applicable to this product.

NCBI GI #
47678569
NCBI GeneID
4248
NCBI Accession #
CAG30405.1
UniProt Primary Accession #
Q09327
UniProt Secondary Accession #
Q14CK5; Q6IC49; Q9UH32; A6NGD0
UniProt Related Accession #
Q09327
NCBI Official Full Name
MGAT3
NCBI Official Synonym Full Names
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
NCBI Official Symbol
MGAT3
NCBI Official Synonym Symbols
GNT3; GNT-III
UniProt Protein Name
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
UniProt Synonym Protein Names
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Protein Family
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
UniProt Gene Name
MGAT3
UniProt Synonym Gene Names
GGNT3; GNT-III; GlcNAc-T III
UniProt Entry Name
MGAT3_HUMAN
NCBI Protein Information
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; GlcNAc-T III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III

NCBI Summary for MGAT3

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for MGAT3

MGAT3: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Belongs to the glycosyltransferase 17 family.

Protein type: EC 2.4.1.144; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
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Research Articles on MGAT3

1. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MGAT3 antibody

 Reference Product  PubMed Publications
 MGAT2 antibody  >8 publications with MGAT3 and MGAT2
 MGAT5 antibody  >4 publications with MGAT3 and MGAT5
 FUT8 antibody  >2 publications with MGAT3 and FUT8
 MGAT5B antibody  >1 publications with MGAT3 and MGAT5B

Pathways associated with anti-MGAT3 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Antennae Elongation In The Medial/trans-Golgi Pathway antibodies  N-glycan Antennae Elongation In The Medial/trans-Golgi Pathway Diagram
 N-glycan Biosynthesis, Complex Type Pathway antibodies  N-glycan Biosynthesis, Complex Type Pathway Diagram
 N-glycan Biosynthesis, Complex Type Pathway antibodies  N-glycan Biosynthesis, Complex Type Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Reactions Specific To The Hybrid N-glycan Synthesis Pathway antibodies  Reactions Specific To The Hybrid N-glycan Synthesis Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-MGAT3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with MGAT3 and Neoplasms
 Nervous System Diseases Antibodies  >8 publications with MGAT3 and Nervous System Diseases
 Liver Neoplasms Antibodies  >6 publications with MGAT3 and Liver Neoplasms
 Liver Diseases Antibodies  >6 publications with MGAT3 and Liver Diseases
 Neoplasms, Experimental Antibodies  >4 publications with MGAT3 and Neoplasms, Experimental
 Inflammation Antibodies  >2 publications with MGAT3 and Inflammation
 Gastrointestinal Diseases Antibodies  >1 publications with MGAT3 and Gastrointestinal Diseases
 Lung Neoplasms Antibodies  >1 publications with MGAT3 and Lung Neoplasms
 Necrosis Antibodies  >1 publications with MGAT3 and Necrosis
 Pain Antibodies  >1 publications with MGAT3 and Pain

Organs/Tissues associated with anti-MGAT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with MGAT3 and Liver
 Blood Antibodies  >10 publications with MGAT3 and Blood
 Brain Antibodies  >9 publications with MGAT3 and Brain
 Ovary Antibodies  >6 publications with MGAT3 and Ovary
 Kidney Antibodies  >6 publications with MGAT3 and Kidney
 Intestine Antibodies  >5 publications with MGAT3 and Intestine
 Embryonic Tissue Antibodies  >3 publications with MGAT3 and Embryonic Tissue
 Nerve Antibodies  >2 publications with MGAT3 and Nerve
 Lung Antibodies  >2 publications with MGAT3 and Lung
 Pancreas Antibodies  >1 publications with MGAT3 and Pancreas
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