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WDR48 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643808

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46,… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WDR48, Polyclonal Antibody
Full Product Name
WDR48, CT (WDR48, KIAA1449, UAF1, WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein, p80)
Product Gene Name
anti-WDR48 antibody
Product Synonym Names
Anti -WDR48, CT (WDR48, KIAA1449, UAF1, WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein, p80)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
76,210 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (39093477..39138155). Location: 3p21.33
OMIM
612167
3D Structure
ModBase 3D Structure for Q8TAF3
Immunogen
WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 610-638 amino acids from the C-terminal region of human WDR48.

Product Categories/Family for anti-WDR48 antibody

Antibodies; Abs to WD Repeat Proteins
Applications Tested/Suitable for anti-WDR48 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-WDR48 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-WDR48 antibody

WDR48 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the WDR48 antibody detected the WDR48 protein (arrow).
Rabbit Anti-WDR48 Polyclonal Antibody – Cat# MBS643808

Immunohistochemistry (IHC) of anti-WDR48 antibody

WDR48 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the WDR48 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-WDR48 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS643808

Flow Cytometry (FC/FACS) of anti-WDR48 antibody

WDR48 Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-WDR48 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS643808

Other Notes

Small volumes of anti-WDR48 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WDR48 purchase

MBS643808 is an antibody targeting WDR48. Also known as WDR48, CT (WDR48, KIAA1449, UAF1, WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein, p80). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WDR48. It may not necessarily be applicable to this product.

NCBI GI #
22713391
NCBI GeneID
57599
NCBI Accession #
AAH37168.1
UniProt Primary Accession #
Q8TAF3
UniProt Secondary Accession #
Q63HJ2; Q658Y1; Q8N3Z1; Q9NSK8; Q9P279; B4DM86; B4DQI2; B4DY84
UniProt Related Accession #
Q8TAF3
NCBI Official Full Name
WDR48 protein
NCBI Official Synonym Full Names
WD repeat domain 48
NCBI Official Symbol
WDR48
NCBI Official Synonym Symbols
P80; UAF1
UniProt Protein Name
WD repeat-containing protein 48
UniProt Synonym Protein Names
USP1-associated factor 1; WD repeat endosomal protein; p80
Protein Family
WD repeat-containing protein
UniProt Gene Name
WDR48
UniProt Synonym Gene Names
KIAA1449; UAF1
UniProt Entry Name
WDR48_HUMAN
NCBI Protein Information
WD repeat-containing protein 48; USP1 associated factor 1; USP1-associated factor 1; WD repeat endosomal protein

UniProt Comments for WDR48

WDR48: an ubiquitous lysosomal WD40 repeat protein. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP.

Protein type: Ubiquitin conjugating system; Vesicle

Chromosomal Location of Human Ortholog: 3p21.33

Cellular Component: intracellular membrane-bound organelle; lysosome; nucleus

Molecular Function: protein binding

Biological Process: skin development; protein deubiquitination; viral reproduction; skeletal morphogenesis; multicellular organism growth; single fertilization; homeostasis of number of cells; embryonic organ development; spermatogenesis; double-strand break repair via homologous recombination; positive regulation of epithelial cell proliferation
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Research Articles on WDR48

1. Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-WDR48 antibody

 Products by Pathway  Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram

Organs/Tissues associated with anti-WDR48 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with WDR48 and Blood
 Eye Antibodies  >1 publications with WDR48 and Eye
 Vascular Antibodies  >1 publications with WDR48 and Vascular
 Ovary Antibodies  >1 publications with WDR48 and Ovary
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