MYOG Antibody – Mouse Monoclonal

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

myogenin: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 1q31-q41

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; chromatin DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: skeletal muscle development; ossification; muscle cell fate commitment; skeletal muscle fiber development; response to muscle activity involved in regulation of muscle adaptation; response to denervation involved in regulation of muscle adaptation; response to electrical stimulus involved in regulation of muscle adaptation; cell cycle; mRNA transcription from RNA polymerase II promoter; positive regulation of myoblast differentiation; negative regulation of cell proliferation; muscle cell differentiation; striated muscle atrophy; positive regulation of muscle atrophy; positive regulation of skeletal muscle fiber development; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of satellite cell proliferation