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TNFSF15 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644126

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TNFSF15, Polyclonal Antibody
Full Product Name
TNFSF15, ID (TNFSF15, TL1, VEGI, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand
Product Gene Name
anti-Tnfsf15 antibody
Product Synonym Names
Anti -TNFSF15, ID (TNFSF15, TL1, VEGI, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
27,723 Da
Chromosome Location
Chromosome: 4; NC_000070.6 (63724603..63745113, complement). Location: 4 C1; 4
3D Structure
ModBase 3D Structure for Q5UBV8
Immunogen
TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human TNFSF15.

Product Categories/Family for anti-Tnfsf15 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-Tnfsf15 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-Tnfsf15 antibody
Suitable for use in Western Blot, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunofluorescence: 1:10-50
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-Tnfsf15 antibody

Western Blot analysis in 293 cell lysates (2ug/lane) using MBS644126 Lane 1: nontransfected Lane 2: transiently transfected with the TNFSF15 gene.
Rabbit Anti-TNFSF15 Polyclonal Antibody – Cat# MBS644126

Immunofluorescence (IF) of anti-Tnfsf15 antibody

Confocal immunofluorescent analysis with Hela cells using MBS644126 followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-TNFSF15 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS644126

Flow Cytometry (FC/FACS) of anti-Tnfsf15 antibody

Flow Cytometric analysis of 293 cells using MBS644126 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-TNFSF15 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS644126

Other Notes

Small volumes of anti-Tnfsf15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tnfsf15 purchase

MBS644126 is an antibody targeting Tnfsf15. Also known as TNFSF15, ID (TNFSF15, TL1, VEGI, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tnfsf15. It may not necessarily be applicable to this product.

NCBI GI #
238776819
NCBI GeneID
326623
NCBI Accession #
NP_796345.3
UniProt Primary Accession #
Q5UBV8
UniProt Secondary Accession #
Q8K3Y8
UniProt Related Accession #
Q5UBV8
GenBank Nucleotide #
NM_177371.3
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 15
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 15
NCBI Official Symbol
Tnfsf15
NCBI Official Synonym Symbols
Tl1; Tl1a; Vegi
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 15
UniProt Synonym Protein Names
TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor
Protein Family
Tumor necrosis factor ligand superfamily
UniProt Gene Name
Tnfsf15
UniProt Synonym Gene Names
Tl1; Vegi
UniProt Entry Name
TNF15_MOUSE
NCBI Protein Information
tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; vascular endothelial growth inhibitor; vascular endothelial cell growth inhibitor; bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15)

UniProt Comments for Tnfsf15

TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine; Apoptosis

Cellular Component: extracellular space; membrane; plasma membrane; integral to membrane; extracellular region

Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding

Biological Process: caspase activation; cytokine metabolic process; apoptosis; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion
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Research Articles on Tnfsf15

1. Both in supernatant and as purified fusion protein, TL1A-Ig binds to TNFRSF25 transfected--but not untransfected--P815 tumor cells as determined by flow cytometry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tnfsf15 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-Tnfsf15 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >135 publications with Tnfsf15 and Necrosis
 Colitis Antibodies  >24 publications with Tnfsf15 and Colitis
 Colitis, Ulcerative Antibodies  >20 publications with Tnfsf15 and Colitis, Ulcerative
 Atherosclerosis Antibodies  >5 publications with Tnfsf15 and Atherosclerosis
 Breast Neoplasms Antibodies  >4 publications with Tnfsf15 and Breast Neoplasms
 Liver Diseases Antibodies  >4 publications with Tnfsf15 and Liver Diseases
 Hyperplasia Antibodies  >3 publications with Tnfsf15 and Hyperplasia
 Cardiovascular Diseases Antibodies  >3 publications with Tnfsf15 and Cardiovascular Diseases
 Fibrosis Antibodies  >3 publications with Tnfsf15 and Fibrosis
 Nervous System Diseases Antibodies  >2 publications with Tnfsf15 and Nervous System Diseases

Organs/Tissues associated with anti-Tnfsf15 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >10 publications with Tnfsf15 and Embryonic Tissue
 Thymus Antibodies  >2 publications with Tnfsf15 and Thymus
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