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Atlastin-1 (ATL1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644134

MBS644134 is an antibody targeting ATL1. Also known as Atlastin-1 (ATL1, Brain-specific GTP-binding Protein, GTP-binding Protein 3, GBP3, GBP-3, hGBP3, Guanine Nucleotide-binding Protein 3, Spastic Paraplegia 3 Protein A, SPG3A). Reactive in Human, Rat. Host:… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Atlastin-1 (ATL1), Monoclonal Antibody
Full Product Name
Atlastin-1 (ATL1, Brain-specific GTP-binding Protein, GTP-binding Protein 3, GBP3, GBP-3, hGBP3, Guanine Nucleotide-binding Protein 3, Spastic Paraplegia 3 Protein A, SPG3A)
Product Gene Name
anti-ATL1 antibody
Product Synonym Names
Anti -Atlastin-1 (ATL1, Brain-specific GTP-binding Protein, GTP-binding Protein 3, GBP3, GBP-3, hGBP3, Guanine Nucleotide-binding Protein 3, Spastic Paraplegia 3 Protein A, SPG3A)
Immunogen Sequence
MAKNRRDRNS WGGFSEKTYE WSSEEEEPVK KAGPVQVLIV KDDHSFELDE TALNRILLSE AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1B9
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SPG3A. Species Crossreactivity: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
63,544 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (50999800..51099786). Location: 14q22.1
OMIM
182600
3D Structure
ModBase 3D Structure for Q8WXF7
Immunogen
Partial recombinant corresponding to aa1-101 from human SPG3A (NP_056999) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-ATL1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-ATL1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ATL1 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-ATL1 antibody

Western Blot detection against Immunogen (37.11kD).
Mouse Anti-ATL1 Monoclonal Antibody – Cat# MBS644134

Western Blot (WB) of anti-ATL1 antibody

SPG3A monoclonal antibody. Western Blot analysis of SPG3A expression in PC-12.
Mouse Anti-ATL1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS644134

Western Blot (WB) of anti-ATL1 antibody

SPG3A monoclonal antibody Western Blot analysis of SPG3A expression in IMR-32.
Mouse Anti-ATL1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS644134

Testing Data of anti-ATL1 antibody

Detection limit for recombinant GST tagged SPG3A is ~1ng/ml as a capture antibody.
Mouse Anti-ATL1 Monoclonal Antibody, Testing Data – Cat# MBS644134

Other Notes

Small volumes of anti-ATL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ATL1. It may not necessarily be applicable to this product.

NCBI GI #
189181742
NCBI GeneID
51062
NCBI Accession #
NP_001121185.1
UniProt Primary Accession #
Q8WXF7
UniProt Secondary Accession #
O95890; Q69YH7; Q96FK0; A6NND5; A8K2C0; G5E9T1
UniProt Related Accession #
Q8WXF7
GenBank Nucleotide #
NM_001127713.1
NCBI Official Full Name
atlastin-1 isoform b
NCBI Official Synonym Full Names
atlastin GTPase 1
NCBI Official Symbol
ATL1
NCBI Official Synonym Symbols
FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
UniProt Protein Name
Atlastin-1
UniProt Synonym Protein Names
Brain-specific GTP-binding protein; GTP-binding protein 3; GBP-3; hGBP3; Guanine nucleotide-binding protein 3; Spastic paraplegia 3 protein A
Protein Family
Alkyltransferase-like protein
UniProt Gene Name
ATL1
UniProt Synonym Gene Names
GBP3; SPG3A; GBP-3; hGBP3
UniProt Entry Name
ATLA1_HUMAN
NCBI Protein Information
atlastin-1; GBP-3; hGBP3; GTP-binding protein 3; guanylate-binding protein 3; spastic paraplegia 3 protein A; brain-specific GTP-binding protein; guanine nucleotide-binding protein 3

NCBI Summary for ATL1

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ATL1

atlastin: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3); also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in ATL1 are the cause of hereditary sensory neuropathy type 1D (HSN1D). HSN1D is a disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Belongs to the GBP family. Atlastin subfamily.

Protein type: Membrane protein, multi-pass; EC 3.6.5.-; Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; axon; integral to membrane; Golgi cis cisterna

Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding

Biological Process: endoplasmic reticulum organization and biogenesis; axonogenesis; metabolic process; protein homooligomerization

Disease: Neuropathy, Hereditary Sensory, Type Id; Spastic Paraplegia 3, Autosomal Dominant
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Research Articles on ATL1

1. Three novel ATL1 mutations are identified in a cohort of patients with upper motor neuron syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATL1 antibody

 Reference Product  PubMed Publications
 SPAST antibody  >29 publications with ATL1 and SPAST
 REEP1 antibody  >6 publications with ATL1 and REEP1
 NIPA1 antibody  >5 publications with ATL1 and NIPA1
 ZFYVE27 antibody  >1 publications with ATL1 and ZFYVE27
 KIAA0196 antibody  >1 publications with ATL1 and KIAA0196

Diseases associated with anti-ATL1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >68 publications with ATL1 and Congenital Abnormalities
 Neurobehavioral Manifestations Antibodies  >8 publications with ATL1 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >7 publications with ATL1 and Brain Diseases
 Autoimmune Diseases Antibodies  >5 publications with ATL1 and Autoimmune Diseases
 Atrophy Antibodies  >4 publications with ATL1 and Atrophy
 Nerve Degeneration Antibodies  >3 publications with ATL1 and Nerve Degeneration
 Mental Disorders Antibodies  >2 publications with ATL1 and Mental Disorders
 Kidney Diseases Antibodies  >1 publications with ATL1 and Kidney Diseases
 Neoplasms Antibodies  >1 publications with ATL1 and Neoplasms
 Spastic paraplegia 3, autosomal dominant Antibodies  >1 publications with ATL1 and Spastic paraplegia 3, autosomal dominant

Organs/Tissues associated with anti-ATL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with ATL1 and Brain
 Nerve Antibodies  >12 publications with ATL1 and Nerve
 Muscle Antibodies  >9 publications with ATL1 and Muscle
 Bone Antibodies  >3 publications with ATL1 and Bone
 Kidney Antibodies  >3 publications with ATL1 and Kidney
 Skin Antibodies  >2 publications with ATL1 and Skin
 Connective Tissue Antibodies  >1 publications with ATL1 and Connective Tissue
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