HIC1 Antibody – Rabbit Polyclonal

HIC1: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF- responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from CXCR7, FGFBP1 and EFNA1. Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Tumor suppressor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: nucleoplasm; cytoplasm; chromatin

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; transcription factor activity

Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; DNA damage response, signal transduction resulting in induction of apoptosis; transcription, DNA-dependent; multicellular organismal development; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter