Rabbit Anti-HNRNPLL Polyclonal Antibody – Cat# MBS644223

HNRPLL Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the HNRPLL antibody detected the HNRPLL protein (arrow).

HNRNPLL Antibody – Rabbit Polyclonal

Name: HNRNPLL Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644223
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644223

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HNRPLL (HNRNPLL), Polyclonal Antibody

Full Product Name

HNRPLL, NT (HNRPLL, SRRF, Heterogeneous nuclear ribonucleoprotein L-like, Stromal RNA-regulating factor)

Product Gene Name

anti-HNRNPLL antibody

Product Synonym Names

Anti -HNRPLL, NT (HNRPLL, SRRF, Heterogeneous nuclear ribonucleoprotein L-like, Stromal RNA-regulating factor)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

60,083 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (38789120..38830178, complement). Location: 2p22.1

OMIM

611208

3D Structure

ModBase 3D Structure for Q8WVV9

Immunogen

HNRPLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-162 amino acids from the N-terminal region of human HNRPLL.

Product Categories/Family for anti-HNRNPLL antibody

Antibodies; Abs to Nuclear Proteins

Applications Tested/Suitable for anti-HNRNPLL antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-HNRNPLL antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-HNRNPLL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HNRNPLL purchase

MBS644223 is an antibody targeting HNRNPLL. Also known as HNRPLL, NT (HNRPLL, SRRF, Heterogeneous nuclear ribonucleoprotein L-like, Stromal RNA-regulating factor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HNRNPLL. It may not necessarily be applicable to this product.

NCBI GI #

20149709

NCBI GeneID

92906

NCBI Accession #

NP_612403.2

UniProt Primary Accession #

Q8WVV9

UniProt Secondary Accession #

Q53T80; Q5JB51; Q659B9; Q8IVH5; Q8IVH6; Q96HR5

UniProt Related Accession #

Q8WVV9

GenBank Nucleotide #

NM_138394.3

NCBI Official Full Name

heterogeneous nuclear ribonucleoprotein L-like isoform 1

NCBI Official Synonym Full Names

heterogeneous nuclear ribonucleoprotein L-like

NCBI Official Symbol

HNRNPLL

NCBI Official Synonym Symbols

SRRF; HNRPLL

UniProt Protein Name

Heterogeneous nuclear ribonucleoprotein L-like

UniProt Synonym Protein Names

Stromal RNA-regulating factor

Protein Family

Heterogeneous nuclear ribonucleoprotein

UniProt Gene Name

HNRNPLL

UniProt Synonym Gene Names

HNRPLL; SRRF; hnRNPLL

UniProt Entry Name

HNRLL_HUMAN

NCBI Protein Information

heterogeneous nuclear ribonucleoprotein L-like; stromal RNA regulating factor; stromal RNA-regulating factor

UniProt Comments for HNRNPLL

HNRPLL: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 2p22.1

Cellular Component: membrane; nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding

Biological Process: mRNA processing; positive regulation of RNA splicing

Research Articles on HNRNPLL

1. Loss-of-function mutation of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote peripheral T cell longevity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HNRNPLL antibody

Reference Product	PubMed Publications
PTPRC antibody	>5 publications with HNRNPLL and PTPRC

Diseases associated with anti-HNRNPLL antibody

Disease Name	Pubmed Publications
Death Antibodies	>1 publications with HNRNPLL and Death
Immune System Diseases Antibodies	>1 publications with HNRNPLL and Immune System Diseases
Lymphopenia Antibodies	>1 publications with HNRNPLL and Lymphopenia

Organs/Tissues associated with anti-HNRNPLL antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>7 publications with HNRNPLL and Blood
Thymus Antibodies	>1 publications with HNRNPLL and Thymus