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CTNNBIP1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644263

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTNNBIP1, Monoclonal Antibody
Full Product Name
CTNNBIP1 (Beta-catenin-interacting Protein 1, Inhibitor of beta-catenin and Tcf-4, ICAT, MGC15093)
Product Gene Name
anti-CTNNBIP1 antibody
Product Synonym Names
Anti -CTNNBIP1 (Beta-catenin-interacting Protein 1, Inhibitor of beta-catenin and Tcf-4, ICAT, MGC15093)
Immunogen Sequence
MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
5C6
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CTNNBIP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
9,170 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (9908334..9970316, complement). Location: 1p36.22
OMIM
607758
3D Structure
ModBase 3D Structure for Q9NSA3
Immunogen
Partial recombinant corresponding to aa1-82 from human CTNNBIP1 (NP_064633) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-CTNNBIP1 antibody

Antibodies; Abs to Catenin
Applications Tested/Suitable for anti-CTNNBIP1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CTNNBIP1 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-CTNNBIP1 antibody

Western Blot detection against Immunogen (35.02kD).
Mouse Anti-CTNNBIP1 Monoclonal Antibody – Cat# MBS644263

Testing Data of anti-CTNNBIP1 antibody

Detection limit for recombinant GST tagged CTNNBIP1 is ~0.1ng/ml as a capture antibody.
Mouse Anti-CTNNBIP1 Monoclonal Antibody, Testing Data – Cat# MBS644263

Other Notes

Small volumes of anti-CTNNBIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTNNBIP1 purchase

MBS644263 is an antibody targeting CTNNBIP1. Also known as CTNNBIP1 (Beta-catenin-interacting Protein 1, Inhibitor of beta-catenin and Tcf-4, ICAT, MGC15093). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNBIP1. It may not necessarily be applicable to this product.

NCBI GI #
187955913
NCBI GeneID
56998
NCBI Accession #
AAI46893.1
UniProt Primary Accession #
Q9NSA3
UniProt Secondary Accession #
Q5T4V2
UniProt Related Accession #
Q9NSA3
NCBI Official Full Name
CTNNBIP1 protein
NCBI Official Synonym Full Names
catenin, beta interacting protein 1
NCBI Official Symbol
CTNNBIP1
NCBI Official Synonym Symbols
ICAT
UniProt Protein Name
Beta-catenin-interacting protein 1
UniProt Synonym Protein Names
Inhibitor of beta-catenin and Tcf-4
Protein Family
Beta-catenin-interacting protein
UniProt Gene Name
CTNNBIP1
UniProt Synonym Gene Names
ICAT
UniProt Entry Name
CNBP1_HUMAN
NCBI Protein Information
beta-catenin-interacting protein 1; inhibitor of beta-catenin and Tcf-4; beta-catenin-interacting protein ICAT

NCBI Summary for CTNNBIP1

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CTNNBIP1

CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family.

Protein type: Inhibitor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; cytoplasm; cytosol; beta-catenin destruction complex; nucleus

Molecular Function: protein binding; beta-catenin binding

Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; ureteric bud branching; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding
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Research Articles on CTNNBIP1

1. beta-catenin was significantly associated with nodal stage, TNM stage, and E-cadherin expression. beta-catenin could be early marker for identification of occult metastases in oral SCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTNNBIP1 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >19 publications with CTNNBIP1 and CTNNB1
 CLSTN1 antibody  >2 publications with CTNNBIP1 and CLSTN1
 UBIAD1 antibody  >1 publications with CTNNBIP1 and UBIAD1

Pathways associated with anti-CTNNBIP1 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with anti-CTNNBIP1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with CTNNBIP1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CTNNBIP1 and Carcinoma, Hepatocellular
 Congenital Abnormalities Antibodies  >1 publications with CTNNBIP1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with CTNNBIP1 and Abnormalities, Multiple
 Hepatomegaly Antibodies  >1 publications with CTNNBIP1 and Hepatomegaly
 Fibrosis Antibodies  >1 publications with CTNNBIP1 and Fibrosis
 Necrosis Antibodies  >1 publications with CTNNBIP1 and Necrosis
 Hyperplasia Antibodies  >1 publications with CTNNBIP1 and Hyperplasia

Organs/Tissues associated with anti-CTNNBIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with CTNNBIP1 and Blood
 Kidney Antibodies  >4 publications with CTNNBIP1 and Kidney
 Liver Antibodies  >3 publications with CTNNBIP1 and Liver
 Eye Antibodies  >3 publications with CTNNBIP1 and Eye
 Connective Tissue Antibodies  >2 publications with CTNNBIP1 and Connective Tissue
 Bone Antibodies  >1 publications with CTNNBIP1 and Bone
 Uncharacterized Tissue Antibodies  >1 publications with CTNNBIP1 and Uncharacterized Tissue
 Prostate Antibodies  >1 publications with CTNNBIP1 and Prostate
 Vascular Antibodies  >1 publications with CTNNBIP1 and Vascular
 Skin Antibodies  >1 publications with CTNNBIP1 and Skin
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