Mouse Anti-MAP3K11 Monoclonal Antibody – Cat# MBS644276

MAP3K11 western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MAP3K11 antibody detected the MAP3K11 protein (arrow).

MAP3K11 Antibody – Mouse Monoclonal

Name: MAP3K11 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644276
Price: 820 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644276

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK… More details

$820 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAP3K11, Monoclonal Antibody

Full Product Name

MAP3K11 (MAP3K11, MLK3, PTK1, SPRK, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase)

Product Gene Name

anti-MAP3K11 antibody

Product Synonym Names

Anti -MAP3K11 (MAP3K11, MLK3, PTK1, SPRK, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase)

Clonality

Monoclonal

Isotype

IgM,k

Clone Number

230CT5.3.1

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid, crude ascites with 0.09% sodium azide.

Purity/Purification

Ascites
Ascites

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

92,688 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (65365226..65381720, complement). Location: 11q13.1-q13.3

OMIM

600050

3D Structure

ModBase 3D Structure for Q16584

Immunogen

MAP3K11 Mab is generated from mouse immunized with MAP3K11 recombinant protein.

Product Categories/Family for anti-MAP3K11 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-MAP3K11 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-MAP3K11 antibody

Suitable for use in Western Blot, ELISA.
Dilution: ELISA: 1:1000
Western Blot: 1:100~500

Other Notes

Small volumes of anti-MAP3K11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAP3K11 purchase

MBS644276 is an antibody targeting MAP3K11. Also known as MAP3K11 (MAP3K11, MLK3, PTK1, SPRK, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MAP3K11. It may not necessarily be applicable to this product.

NCBI GI #

4505195

NCBI GeneID

4296

NCBI Accession #

NP_002410.1

UniProt Primary Accession #

Q16584

UniProt Secondary Accession #

Q53H00; Q59F06; Q6P2G4

UniProt Related Accession #

Q16584

GenBank Nucleotide #

NM_002419.3

NCBI Official Full Name

mitogen-activated protein kinase kinase kinase 11

NCBI Official Synonym Full Names

mitogen-activated protein kinase kinase kinase 11

NCBI Official Symbol

MAP3K11

NCBI Official Synonym Symbols

MLK3; PTK1; SPRK; MLK-3; MEKK11

UniProt Protein Name

Mitogen-activated protein kinase kinase kinase 11

UniProt Synonym Protein Names

Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase

Protein Family

Mitogen-activated protein kinase kinase kinase

UniProt Gene Name

MAP3K11

UniProt Synonym Gene Names

MLK3; PTK1; SPRK

UniProt Entry Name

M3K11_HUMAN

NCBI Protein Information

mitogen-activated protein kinase kinase kinase 11; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3 domain-containing proline-rich kinase

UniProt Comments for MAP3K11

MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7.

Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 11q13.1-q13.3

Cellular Component: microtubule; centrosome; membrane; cytoplasm

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; JUN kinase kinase kinase activity; protein homodimerization activity; mitogen-activated protein kinase kinase binding; protein-tyrosine kinase activity; Rac GTPase binding; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity

Biological Process: cell death; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of JNK cascade; protein amino acid phosphorylation; activation of JNK activity; microtubule-based process; cell proliferation; positive regulation of neuron apoptosis; JNK cascade; activation of JNKK activity

Research Articles on MAP3K11

1. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAP3K11 antibody

Reference Product	PubMed Publications
MAP3K1 antibody	>1 publications with MAP3K11 and MAP3K1

Pathways associated with anti-MAP3K11 antibody

Products by Pathway	Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram
IFN-gamma Pathway antibodies	IFN-gamma Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies	Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies	Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
RAC1 Signaling Pathway antibodies	RAC1 Signaling Pathway Diagram
Reelin Signaling Pathway antibodies	Reelin Signaling Pathway Diagram

Diseases associated with anti-MAP3K11 antibody

Disease Name	Pubmed Publications
Hearing Loss Antibodies	>1 publications with MAP3K11 and Hearing Loss
Nervous System Diseases Antibodies	>1 publications with MAP3K11 and Nervous System Diseases
Immune System Diseases Antibodies	>1 publications with MAP3K11 and Immune System Diseases
Breast Neoplasms Antibodies	>1 publications with MAP3K11 and Breast Neoplasms
Inflammation Antibodies	>1 publications with MAP3K11 and Inflammation

Organs/Tissues associated with anti-MAP3K11 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with MAP3K11 and Testis
Blood Antibodies	>1 publications with MAP3K11 and Blood
Adrenal Gland Antibodies	>1 publications with MAP3K11 and Adrenal Gland
Uterus Antibodies	>1 publications with MAP3K11 and Uterus
Prostate Antibodies	>1 publications with MAP3K11 and Prostate