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PIK3C2A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644311

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PIK3C2A, Polyclonal Antibody
Full Product Name
PIK3C2A, CT (PIK3C2A, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, Phosphoinositide 3-kinase-C2-alpha)
Product Gene Name
anti-PIK3C2A antibody
Product Synonym Names
Anti -PIK3C2A, CT (PIK3C2A, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, Phosphoinositide 3-kinase-C2-alpha)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
190,680 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (17108108..17229543, complement). Location: 11p15.5-p14
OMIM
603601
3D Structure
ModBase 3D Structure for O00443
Immunogen
PIK3C2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1438-1466 amino acids from the C-terminal region of human PIK3C2A.

Product Categories/Family for anti-PIK3C2A antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PIK3C2A antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PIK3C2A antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-PIK3C2A antibody

PIK3C2A Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PIK3C2A antibody detected the PIK3C2A protein (arrow).
Rabbit Anti-PIK3C2A Polyclonal Antibody – Cat# MBS644311

Immunohistochemistry (IHC) of anti-PIK3C2A antibody

PIK3C2A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PIK3C2A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PIK3C2A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS644311

Other Notes

Small volumes of anti-PIK3C2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIK3C2A purchase

MBS644311 is an antibody targeting PIK3C2A. Also known as PIK3C2A, CT (PIK3C2A, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, Phosphoinositide 3-kinase-C2-alpha). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIK3C2A. It may not necessarily be applicable to this product.

NCBI GI #
157671929
NCBI GeneID
5286
NCBI Accession #
NP_002636.2
UniProt Primary Accession #
O00443
UniProt Secondary Accession #
Q14CQ9; B0LPH2
UniProt Related Accession #
O00443
GenBank Nucleotide #
NM_002645.2
NCBI Official Full Name
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
NCBI Official Symbol
PIK3C2A
NCBI Official Synonym Symbols
CPK; PI3-K-C2A; PI3-K-C2(ALPHA)
UniProt Protein Name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
UniProt Synonym Protein Names
Phosphoinositide 3-kinase-C2-alpha
Protein Family
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing
UniProt Gene Name
PIK3C2A
UniProt Synonym Gene Names
PI3K-C2-alpha
UniProt Entry Name
P3C2A_HUMAN
NCBI Protein Information
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha; C2-containing phosphatidylinositol kinase; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha

UniProt Comments for PIK3C2A

PIK3C2A: a protein of the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. Its PI3-kinase is not sensitive to nanomolar levels of the inhibitor wortmannin. Activated by insulin and may be involved in integrin-dependent signaling.

Protein type: Kinase, lipid; Autophagy; EC 2.7.1.154; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 11p15.5-p14

Cellular Component: Golgi apparatus; clathrin-coated vesicle; membrane; cytoplasm; plasma membrane; phosphoinositide 3-kinase complex; nucleus; cytosol; vesicle

Molecular Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; phosphoinositide 3-kinase activity; phosphoinositide binding; phosphatidylinositol-4-phosphate 3-kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; clathrin cage assembly; exocytosis; phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; vascular smooth muscle contraction; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; endocytosis
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Research Articles on PIK3C2A

1. Class II enzyme PI3K-C2beta and the class IB isozyme p110gamma mainly regulate the S1P- and high density lipoprotein (HDL)-dependent endothelial cell (EC) migration and PI3K-C2alpha primarily controls EC survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PIK3C2A antibody

 Reference Product  PubMed Publications
 PTEN antibody  >2 publications with PIK3C2A and PTEN

Pathways associated with anti-PIK3C2A antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-PIK3C2A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with PIK3C2A and Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with PIK3C2A and Carcinoma, Squamous Cell
 Learning Disorders Antibodies  >1 publications with PIK3C2A and Learning Disorders
 Prostatic Diseases Antibodies  >1 publications with PIK3C2A and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >1 publications with PIK3C2A and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >1 publications with PIK3C2A and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with PIK3C2A and Kidney Diseases

Organs/Tissues associated with anti-PIK3C2A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with PIK3C2A and Blood
 Lung Antibodies  >2 publications with PIK3C2A and Lung
 Prostate Antibodies  >2 publications with PIK3C2A and Prostate
 Brain Antibodies  >2 publications with PIK3C2A and Brain
 Kidney Antibodies  >1 publications with PIK3C2A and Kidney
 Muscle Antibodies  >1 publications with PIK3C2A and Muscle
 Lymph Node Antibodies  >1 publications with PIK3C2A and Lymph Node
 Intestine Antibodies  >1 publications with PIK3C2A and Intestine
 Pancreas Antibodies  >1 publications with PIK3C2A and Pancreas
 Bone Antibodies  >1 publications with PIK3C2A and Bone
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