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DMGDH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644351

This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as… More details

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Product Overview

Online Datasheet in PDF
Product Name
DMGDH, Polyclonal Antibody
Full Product Name
DMGDH, CT (DMGDH, Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH)
Product Gene Name
Product Synonym Names
Anti -DMGDH, CT (DMGDH, Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
96,811 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (78293387..78365497, complement). Location: 5q14.1
OMIM
605849
3D Structure
ModBase 3D Structure for Q9UI17
Immunogen
DMGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 835-864 amino acids from the C-terminal region of human DMGDH.
Applications Tested/Suitable for anti-DMGDH antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-DMGDH antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-DMGDH antibody

DMGDH Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the DMGDH antibody detected the DMGDH protein (arrow).
Rabbit Anti-DMGDH Polyclonal Antibody – Cat# MBS644351

Other Notes

Small volumes of anti-DMGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DMGDH purchase

MBS644351 is an antibody targeting DMGDH. Also known as DMGDH, CT (DMGDH, Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DMGDH. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
DMGDH protein, partial
NCBI Official Synonym Full Names
dimethylglycine dehydrogenase
NCBI Official Symbol
DMGDH
NCBI Official Synonym Symbols
DMGDHD; ME2GLYDH
UniProt Protein Name
Dimethylglycine dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ME2GLYDH
UniProt Gene Name
DMGDH
UniProt Entry Name
M2GD_HUMAN
NCBI Protein Information
dimethylglycine dehydrogenase, mitochondrial

NCBI Summary for DMGDH

This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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UniProt Comments for DMGDH

DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family.

Protein type: Mitochondrial; EC 1.5.8.4; Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: mitochondrial matrix

Molecular Function: electron carrier activity; dimethylglycine dehydrogenase activity

Biological Process: glycine metabolic process; choline metabolic process; betaine catabolic process

Disease: Dimethylglycine Dehydrogenase Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-DMGDH antibody

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