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RASEF Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644441

MBS644441 is an antibody targeting RASEF. Also known as RASEF (Ras and EF-hand Domain-containing Protein, Ras-related Protein Rab-45, RAB45). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RASEF, Monoclonal Antibody
Full Product Name
RASEF (Ras and EF-hand Domain-containing Protein, Ras-related Protein Rab-45, RAB45)
Product Gene Name
anti-RASEF antibody
Product Synonym Names
Anti -RASEF (Ras and EF-hand Domain-containing Protein, Ras-related Protein Rab-45, RAB45)
Immunogen Sequence
NIREWVDMIE DAAHETVPIM LVGNKADIRD TAATEGQKCV PGHFGEKLAM TYGALFCETS AKDGSNIVEA VLHLAREVKK RTDKDDSRSI TNLTGTNSKK SPQMKNCCNG
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2D5
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human RASEF.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
82,879 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (85594500..85678043, complement). Location: 9q21.32
OMIM
611344
3D Structure
ModBase 3D Structure for Q8IZ41
Immunogen
Partial recombinant protein corresponding to aa631-740 from human RASEF (AAH23566) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-RASEF antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-RASEF antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RASEF antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-RASEF antibody

Western Blot detection against Immunogen (38.1kD).
Mouse Anti-RASEF Monoclonal Antibody – Cat# MBS644441

Western Blot (WB) of anti-RASEF antibody

RASEF monoclonal antibody, Western Blot analysis of RASEF expression in K-562.
Mouse Anti-RASEF Monoclonal Antibody, Western Blot (WB) – Cat# MBS644441

Immunohistochemistry (IHC) of anti-RASEF antibody

Immunoperoxidase of monoclonal antibody to RASEF on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 3ug/ml].
Mouse Anti-RASEF Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS644441

Testing Data of anti-RASEF antibody

Detection limit for recombinant GST tagged RASEF is ~0.3ng/ml as a capture antibody.
Mouse Anti-RASEF Monoclonal Antibody, Testing Data – Cat# MBS644441

Other Notes

Small volumes of anti-RASEF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RASEF. It may not necessarily be applicable to this product.

NCBI GI #
40255119
NCBI GeneID
158158
NCBI Accession #
NP_689786.2
UniProt Primary Accession #
Q8IZ41
UniProt Secondary Accession #
Q96N04; A6NC29
UniProt Related Accession #
Q8IZ41
GenBank Nucleotide #
NM_152573.3
NCBI Official Full Name
ras and EF-hand domain-containing protein
NCBI Official Synonym Full Names
RAS and EF-hand domain containing
NCBI Official Symbol
RASEF
NCBI Official Synonym Symbols
RAB45
UniProt Protein Name
Ras and EF-hand domain-containing protein
UniProt Synonym Protein Names
Ras-related protein Rab-45
Protein Family
Ras and EF-hand domain-containing protein
UniProt Gene Name
RASEF
UniProt Synonym Gene Names
RAB45
UniProt Entry Name
RASEF_HUMAN
NCBI Protein Information
ras and EF-hand domain-containing protein; ras-related protein Rab-45

NCBI Summary for RASEF

This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]
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UniProt Comments for RASEF

RASEF: Binds predominantly GDP, and also GTP. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric, Rab; G protein, monomeric; G protein

Chromosomal Location of Human Ortholog: 9q21.32

Cellular Component: perinuclear region of cytoplasm; endomembrane system

Molecular Function: GTPase activity; GDP binding; GTP binding; calcium ion binding

Biological Process: regulation of exocytosis; intracellular protein transport; metabolic process; protein secretion; Rab protein signal transduction; vesicle docking during exocytosis
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Research Articles on RASEF

1. overexpression of RAB45 increased the phosphorylation levels of p38, resulting in the induction of apoptosis and inhibition of proliferation of CML progenitor cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RASEF antibody

 Reference Product  PubMed Publications
 CD34 antibody  >2 publications with RASEF and CD34
 KIF27 antibody  >1 publications with RASEF and KIF27
 SLC28A3 antibody  >1 publications with RASEF and SLC28A3
 C9orf103 antibody  >1 publications with RASEF and C9orf103
 FRMD3 antibody  >1 publications with RASEF and FRMD3
 C9orf64 antibody  >1 publications with RASEF and C9orf64

Diseases associated with anti-RASEF antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with RASEF and Neoplasms
 Eye Diseases Antibodies  >2 publications with RASEF and Eye Diseases
 Chromosome Aberrations Antibodies  >1 publications with RASEF and Chromosome Aberrations
 Breast Neoplasms Antibodies  >1 publications with RASEF and Breast Neoplasms

Organs/Tissues associated with anti-RASEF antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with RASEF and Skin
 Lung Antibodies  >1 publications with RASEF and Lung
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