Rabbit Anti-FCN1 Polyclonal Antibody – Cat# MBS644484

Western Blot analysis in K562 cell line lysates (35ug/lane) using MBS644484. This demonstrates that MBS644484 detected the FCN1 protein (arrow).

FCN1 Antibody – Rabbit Polyclonal

Name: FCN1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS644484
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644484

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FCN1, Polyclonal Antibody

Full Product Name

FCN1, CT (FCN1, FCNM, Ficolin-1, Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin)

Product Gene Name

anti-FCN1 antibody

Product Synonym Names

Anti -FCN1, CT (FCN1, FCNM, Ficolin-1, Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

35,078 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (137797711..137809849, complement). Location: 9q34

OMIM

601252

3D Structure

ModBase 3D Structure for O00602

Immunogen

FCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-267 amino acids from the C-terminal region of human FCN1.

Product Categories/Family for anti-FCN1 antibody

Antibodies; Abs to Fibrinogen

Applications Tested/Suitable for anti-FCN1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-FCN1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-FCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCN1 purchase

MBS644484 is an antibody targeting FCN1. Also known as FCN1, CT (FCN1, FCNM, Ficolin-1, Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCN1. It may not necessarily be applicable to this product.

NCBI GI #

8051584

NCBI GeneID

2219

NCBI Accession #

NP_001994.2

UniProt Primary Accession #

O00602

UniProt Secondary Accession #

Q5VYV5; Q92596

UniProt Related Accession #

O00602

GenBank Nucleotide #

NM_002003.3

NCBI Official Full Name

ficolin-1

NCBI Official Synonym Full Names

ficolin (collagen/fibrinogen domain containing) 1

NCBI Official Symbol

FCN1

NCBI Official Synonym Symbols

FCNM

UniProt Protein Name

Ficolin-1

UniProt Synonym Protein Names

Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin

Protein Family

Ficolin

UniProt Gene Name

FCN1

UniProt Synonym Gene Names

FCNM

UniProt Entry Name

FCN1_HUMAN

NCBI Protein Information

ficolin-1; M-ficolin; ficolin-A; ficolin-alpha; collagen/fibrinogen domain-containing protein 1; ficolin (collagen/fibrinogen domain-containing) 1

UniProt Comments for FCN1

FCN1: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Belongs to the ficolin lectin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extrinsic to external side of plasma membrane; collagen; extracellular region

Molecular Function: protein binding; G-protein-coupled receptor binding; metal ion binding; carbohydrate binding; sialic acid binding; pattern recognition receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; complement activation

Research Articles on FCN1

1. M-ficolin bound strongly to serotype 19B and 19C polysaccharides.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCN1 antibody

Reference Product	PubMed Publications
MASP1 antibody	>2 publications with FCN1 and MASP1
CD14 antibody	>1 publications with FCN1 and CD14

Pathways associated with anti-FCN1 antibody

Products by Pathway	Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies	Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram

Diseases associated with anti-FCN1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>3 publications with FCN1 and Inflammation
Inflammatory Bowel Diseases Antibodies	>1 publications with FCN1 and Inflammatory Bowel Diseases
Gastrointestinal Diseases Antibodies	>1 publications with FCN1 and Gastrointestinal Diseases

Organs/Tissues associated with anti-FCN1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with FCN1 and Blood
Bone Antibodies	>1 publications with FCN1 and Bone
Brain Antibodies	>1 publications with FCN1 and Brain
Bone Marrow Antibodies	>1 publications with FCN1 and Bone Marrow
Intestine Antibodies	>1 publications with FCN1 and Intestine
Lung Antibodies	>1 publications with FCN1 and Lung